Avulsion fracture

Aromatase Inhibitor

A molecular structure of an aromatase inhibitor.

An aromatase inhibitor (AI) is a type of drug that plays a crucial role in the treatment of hormone-dependent breast cancer in postmenopausal women. By inhibiting the aromatase enzyme, aromatase inhibitors prevent the conversion of androgens into estrogens, particularly estradiol, the predominant form of estrogen in postmenopausal women. This reduction in estrogen levels is beneficial in slowing the growth of hormone receptor-positive breast cancer.

Overview

Aromatase inhibitors are part of hormone therapy used to treat breast cancer that is estrogen receptor-positive. They are most effective in postmenopausal women, where the primary source of estrogen is through the conversion of androgens (produced by the adrenal glands) into estrogens, a process catalyzed by the aromatase enzyme.

Types of Aromatase Inhibitors

There are three main types of aromatase inhibitors, which differ in their structure and the way they inhibit the aromatase enzyme:

• Anastrozole (Arimidex)
• Letrozole (Femara)
• Exemestane (Aromasin)

Mechanism of Action

Aromatase inhibitors work by binding to the aromatase enzyme, thereby preventing the conversion of androgens to estrogens. This decrease in estrogen levels starves hormone receptor-positive breast cancer cells of their growth signal.

Clinical Use

• Breast Cancer Treatment: Aromatase inhibitors are used as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer. They may also be used in neoadjuvant settings to shrink tumors before surgery.
• Prevention: In some cases, aromatase inhibitors are used to prevent breast cancer in high-risk postmenopausal women.

Side Effects

While effective, aromatase inhibitors can cause side effects, including:

• Bone density loss, leading to osteoporosis
• Joint and muscle pain
• Hot flashes
• Increased risk of cardiovascular disease

Also see

• Traumatic fracture -  This is a fracture due to trauma. e.g.- Fractures caused by a fall, road traffic accident, fight and many others

• Pathological fracture -  A fracture of bone due to certain disease that has made bone weak is called pathological fracture. e.g.- a fracture through a bone weakened by metastasis. Osteoporosis is the most common cause of pathological fracture.

• Closed fracture - Are those in which the skin is intact

• Open fracture - Involve wounds that communicate with the fracture, and may thus expose bone to contamination. Open injuries carry a higher risk of infection.

• Complete fracture - A fracture in which bone fragments separate completely.

• Incomplete fracture - A fracture in which the bone fragments are still partially joined. In such cases, there is a crack in the osseous tissue that does not completely traverse the width of the bone.

• Linear fracture - A fracture that is parallel to the bone's long axis.

• Transverse fracture - A fracture that is at a right angle to the bone's long axis.

• Oblique fracture - A fracture that is diagonal to a bone's long axis.

• Spiral fracture - A fracture where at least one part of the bone has been twisted.

• Comminuted fracture - A fracture in which the bone has broken into several pieces.

• Impacted fracture - A fracture caused when bone fragments are driven into each other.

See Also

• Breast cancer
• Hormone therapy for breast cancer
• Estrogen
• Menopause

References

• Placeholder for references. Use the format:
• Additional references on the efficacy and side effects of aromatase inhibitors.

External Links

• [Placeholder for link to American Cancer Society's page on aromatase inhibitors]
• [Placeholder for link to a detailed review on the mechanism of action of aromatase inhibitors]

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