BCTC (drug)
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BCTC is a chemical compound that acts as a selective antagonist of the TRPM8 receptor, which is a member of the transient receptor potential channel family. This receptor is primarily involved in the sensation of cold temperatures and the cooling effects of compounds like menthol.
Pharmacology[edit | edit source]
BCTC is known for its ability to block the TRPM8 receptor, which is expressed in sensory neurons. The TRPM8 receptor is activated by cold temperatures and cooling agents, and its blockade by BCTC can lead to altered sensations of temperature. This makes BCTC a compound of interest in the study of thermoregulation and pain management.
Mechanism of Action[edit | edit source]
BCTC binds to the TRPM8 receptor and inhibits its activation by cold temperatures and menthol. This inhibition prevents the influx of calcium ions that would normally occur upon receptor activation, thereby modulating the sensory perception of cold.
Therapeutic Potential[edit | edit source]
Research into BCTC has suggested potential applications in the treatment of conditions such as chronic pain, where modulation of sensory perception could provide relief. However, as of the latest research, BCTC remains primarily a tool for scientific investigation rather than a therapeutic agent.
Chemical Properties[edit | edit source]
BCTC is a benzofuran derivative with the IUPAC name 1-(1-Benzofuran-2-yl)-2-(methylamino)propan-1-one. It has a molecular weight of 191.23 g/mol and is typically administered in research settings via oral or intravenous routes.
Research and Development[edit | edit source]
BCTC has been used extensively in laboratory settings to study the TRPM8 receptor and its role in sensory perception. Its ability to selectively block this receptor makes it a valuable tool in the field of neuroscience and pharmacology.
Safety and Toxicology[edit | edit source]
As a research chemical, BCTC's safety profile is not fully established for human use. Studies in animal models have been conducted to assess its pharmacokinetics and potential toxicological effects, but further research is needed to fully understand its safety.
Also see[edit | edit source]
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