CYP2C9*3
CYP2C9*3 is a variant allele of the CYP2C9 gene, which encodes an enzyme belonging to the cytochrome P450 superfamily. This enzyme is primarily involved in the metabolism of various drugs in the human body. The CYP2C9*3 allele is characterized by a single nucleotide polymorphism (SNP) that results in an amino acid substitution at position 144, where isoleucine is replaced by leucine (Ile144Leu). This genetic variation can significantly affect the enzyme's activity, leading to altered drug metabolism.
Function[edit | edit source]
The CYP2C9 enzyme plays a crucial role in the oxidative metabolism of a wide range of therapeutic drugs, including warfarin, phenytoin, tolbutamide, and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and celecoxib. The presence of the CYP2C9*3 allele is associated with reduced enzymatic activity, which can lead to slower drug clearance and increased risk of adverse drug reactions.
Clinical Significance[edit | edit source]
Individuals carrying the CYP2C9*3 allele may require dose adjustments for medications metabolized by CYP2C9 to avoid toxicity. For example, patients with this allele who are prescribed warfarin may need lower doses to achieve therapeutic anticoagulation without increasing the risk of bleeding. Pharmacogenetic testing for CYP2C9 variants, including CYP2C9*3, can help guide personalized medicine approaches to optimize drug therapy and minimize adverse effects.
Genetic Testing[edit | edit source]
Genetic testing for CYP2C9*3 is available and can be performed using various methods, including polymerase chain reaction (PCR) and DNA sequencing. Testing is particularly recommended for patients who are starting medications with a narrow therapeutic index that are metabolized by CYP2C9.
Population Genetics[edit | edit source]
The frequency of the CYP2C9*3 allele varies among different populations. It is more commonly found in individuals of European descent compared to those of African or Asian ancestry. Understanding the distribution of this allele can help in assessing the risk of drug interactions and adverse effects in diverse populations.
Also see[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
