Cornea plana 1

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Cornea plana 1
File:Autosomal dominant - en.svg
Synonyms	Flat cornea
Pronounce	N/A
Specialty	N/A
Symptoms	Reduced visual acuity, hyperopia, astigmatism
Complications	Keratoconus, glaucoma
Onset	Congenital
Duration	Lifelong
Types	N/A
Causes	Genetic mutation in the KERA gene
Risks	Family history of the condition
Diagnosis	Slit lamp examination, corneal topography
Differential diagnosis	Keratoconus, sclerocornea
Prevention	N/A
Treatment	Corrective lenses, corneal transplant
Medication	N/A
Prognosis	Variable, depending on severity
Frequency	Rare
Deaths	N/A

Cornea Plana 1

Cornea Plana 1 is a rare genetic disorder characterized by a significantly flatter cornea than normal. This condition affects the refractive power of the eye, leading to vision problems such as hyperopia (farsightedness) and astigmatism.

Genetics

Cornea Plana 1 is caused by mutations in the KERA gene, which is responsible for encoding the protein keratocan. Keratocan is essential for maintaining the normal curvature and transparency of the cornea. The disorder is inherited in an autosomal recessive pattern, meaning that an individual must inherit two copies of the mutated gene, one from each parent, to be affected.

Symptoms

Individuals with Cornea Plana 1 may experience:

• Reduced visual acuity
• Increased sensitivity to light (photophobia)
• Astigmatism
• Hyperopia

Diagnosis

Diagnosis of Cornea Plana 1 typically involves a comprehensive eye examination by an ophthalmologist. This may include:

• Keratometry to measure the curvature of the cornea
• Corneal topography to map the surface of the cornea
• Genetic testing to identify mutations in the KERA gene

Treatment

There is currently no cure for Cornea Plana 1, but treatment focuses on managing symptoms and improving vision. Options may include:

• Corrective lenses such as glasses or contact lenses
• Refractive surgery in some cases, although this is less common

See Also

• Cornea
• Genetic disorders
• Ophthalmology

References

• Article on Cornea Plana 1
• Autosomal Recessive Inheritance