Dorzolamide/timolol

Dorzolamide

Timolol

Dorzolamide/timolol eyedrops, commercially known as Cosopt, are a vital pharmaceutical intervention for the management of ocular hypertension and glaucoma. By combining two active ingredients, dorzolamide hydrochloride and timolol maleate, Cosopt functions as a potent intraocular pressure-lowering agent.

Composition

Cosopt brings together two significant compounds:

• Dorzolamide hydrochloride: A carbonic anhydrase inhibitor that diminishes the rate of aqueous humor secretion.
• Timolol maleate: A non-selective beta-adrenergic receptor antagonist, also known as a beta-blocker, that further reduces the synthesis of aqueous humor.

The synergistic effect of these components results in a notable reduction of intraocular pressure.

Indications

Cosopt is primarily prescribed for:

• Glaucoma: A group of eye diseases leading to optic nerve damage, often due to elevated intraocular pressure.
• Ocular hypertension: Elevated pressure in the eye without any evident optic nerve damage. It's considered a risk factor for developing glaucoma.

Mechanism of Action

Both components in Cosopt primarily act by curbing the production of aqueous humor, the clear fluid in the front of the eye. By decreasing its formation, intraocular pressure is maintained within normal levels, thereby preventing or mitigating the damage to the optic nerve.

Approval and Manufacturer

• FDA Approval: Dorzolamide/timolol eyedrops were granted approval by the Food and Drug Administration (FDA) in April 1998.
• Manufacturer: The drug is produced and supplied by Merck, a global healthcare company renowned for its innovative pharmaceuticals.

Contraindications and Precautions

Patients with certain medical conditions or on specific medications should consult their physician before using Cosopt. Known contraindications include severe respiratory conditions, specific cardiac disorders, and hypersensitivity to any component of the formulation.

Conclusion

Dorzolamide/timolol eyedrops (Cosopt) represents a significant advancement in the field of ophthalmology, offering an effective solution for managing conditions characterized by elevated intraocular pressure. As with all medications, patients are advised to be informed about potential side effects and to use the drug as directed by a healthcare professional.

External links

• The drug's web site
• The drug's label