Hemolytic–uremic syndrome

Hemolytic–uremic syndrome (HUS) is a group of blood disorders characterized by low red blood cells, acute kidney failure, and low platelets. Initial symptoms typically include bloody diarrhea, fever, and vomiting. Long term complications may include high blood pressure and kidney disease.

Causes

HUS is usually caused by E. coli infection, specifically strain O157:H7, but can also be caused by other types of bacteria. Other causes can include pregnancy, certain medications, and cancer.

Diagnosis

Diagnosis is typically based on blood tests and urine tests. A biopsy of the kidney may also be done.

Treatment

Treatment may include dialysis, steroids, blood transfusion, and kidney transplant in severe cases.

Prognosis

The prognosis for HUS is generally good with appropriate treatment, but it can be life-threatening.

See also

• Thrombotic thrombocytopenic purpura
• Atypical hemolytic uremic syndrome
• Shiga toxin

References

Hemolytic–uremic syndrome Resources
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