Hyperuricemia

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(Redirected from Hereditary hyperuricemia)

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Hyperuricemia
Synonyms High uric acid
Pronounce N/A
Specialty N/A
Symptoms Joint pain, kidney stones, tophi
Complications Gout, chronic kidney disease
Onset Middle age
Duration Long term
Types N/A
Causes Diet, genetics, obesity, diuretics
Risks Hypertension, metabolic syndrome
Diagnosis Blood test
Differential diagnosis Pseudogout, septic arthritis
Prevention Dietary changes, weight loss
Treatment Allopurinol, febuxostat, probenecid
Medication NSAIDs, colchicine
Prognosis N/A
Frequency Common
Deaths N/A


Hyperuricemia refers to a condition characterized by elevated blood concentrations of uric acid, a waste product in the blood that can result from the breakdown of purines.

Pathophysiology[edit]

Uric acid is typically filtered out of the blood by the kidneys and excreted in urine. Hyperuricemia occurs when there is an increase in uric acid production, a decrease in uric acid excretion, or a combination of both.

Causes[edit]

Common causes of hyperuricemia include:

  • Genetic predisposition
  • High-purine diet
  • Obesity
  • Certain medications (e.g., diuretics)
  • Renal impairment
  • Diseases like leukemia or psoriasis

Symptoms and Complications[edit]

While hyperuricemia itself is often asymptomatic, it can lead to serious complications like:

  • Gout
  • Kidney stones
  • Renal dysfunction

Diagnosis[edit]

Diagnosis of hyperuricemia is usually made through blood tests that measure uric acid levels.

Treatment[edit]

Treatment focuses on reducing uric acid levels through:

  • Medications (e.g., allopurinol, febuxostat)
  • Dietary modifications to reduce purine intake
  • Weight loss and lifestyle changes
  • Increased fluid intake

Prevention[edit]

Preventive measures include:

  • Maintaining a healthy weight
  • Avoiding excessive alcohol consumption
  • Limiting intake of high-purine foods
  • Staying well-hydrated

Epidemiology[edit]

Hyperuricemia is a common condition, particularly among men and postmenopausal women, and its prevalence has been increasing worldwide.

See Also[edit]

References[edit]

External Links[edit]

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