KDM3A

KDM3A (also known as JHDM2A or JMJD1A) is a human gene that encodes for the lysine-specific demethylase 3A. This protein is a member of the Jumonji domain-containing protein family and plays a crucial role in histone demethylation, gene transcription, metabolism, and cell differentiation.

Function

KDM3A is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, which are usually associated with repressed chromatin. It plays a central role in spermatogenesis by regulating expression of target genes such as protamine 1 and protamine 2 and other genes involved in the differentiation of germ cells.

Clinical Significance

Alterations in the KDM3A gene have been associated with various diseases. Overexpression of KDM3A has been observed in several types of cancer, including breast cancer, prostate cancer, and lung cancer. It has also been implicated in obesity and type 2 diabetes due to its role in metabolic regulation.

Research

Research into KDM3A is ongoing, with studies focusing on its role in cancer progression and metabolic diseases. Understanding the function and regulation of KDM3A could potentially lead to new therapeutic strategies for these diseases.

See Also

• Histone demethylase
• Jumonji domain-containing protein
• Spermatogenesis
• Protamine