Manidipine
Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. The substance belongs to the class of dihydropyridines and has antihypertensive properties. Manidipine is not registered for use in all countries.
Pharmacology[edit | edit source]
Manidipine is a potent vasodilator due to its strong affinity for L-type calcium channels that are present in the smooth muscle cells of the arterial wall. The blockade of these channels inhibits the influx of calcium ions, which prevents the contraction of the smooth muscle cells and leads to their relaxation. This results in a decrease in peripheral vascular resistance, leading to a decrease in blood pressure.
Clinical Use[edit | edit source]
Manidipine is used for the treatment of hypertension. It may be used alone or in combination with other antihypertensive drugs. The drug has a long duration of action that allows for once-daily dosing. Manidipine is well tolerated and has a favorable side effect profile.
Side Effects[edit | edit source]
The most common side effects of manidipine are related to its vasodilatory action and include flushing, headache, palpitations, and ankle swelling. Other side effects can include dizziness, fatigue, and nausea.
Contraindications[edit | edit source]
Manidipine is contraindicated in patients with known hypersensitivity to dihydropyridines. It should be used with caution in patients with severe cardiac insufficiency or in patients with severe hepatic impairment.
Interactions[edit | edit source]
Manidipine can interact with other drugs, such as beta-blockers, ACE inhibitors, and diuretics, which can lead to additive antihypertensive effects. It can also interact with CYP3A4 inhibitors, which can increase the plasma concentration of manidipine.
See Also[edit | edit source]
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