Maspin
Maspin (Mammary Serine Protease Inhibitor) is a protein that in humans is encoded by the SERPINB5 gene. It is a member of the serpin family of serine protease inhibitors. Maspin plays a crucial role in inhibiting tumor growth and metastasis in certain types of cancer, including breast cancer and prostate cancer.
Function[edit]
Maspin is a non-inhibitory serpin that acts as a tumor suppressor. It is found in normal epithelial cells and has been reported to be downregulated in a number of cancers. Maspin can inhibit cell migration and invasion, induce apoptosis, and disrupt angiogenesis. The exact mechanism of how maspin exerts its effects is still under investigation.
Clinical significance[edit]
The role of maspin in cancer has been widely studied. It has been found that maspin expression is often lost or reduced in cancerous cells compared to normal cells. This loss of expression is associated with a more aggressive tumor phenotype and poorer prognosis in several types of cancer, including breast and prostate cancer. Therefore, maspin is considered a potential therapeutic target in cancer treatment.
See also[edit]
References[edit]
External links[edit]
| Proteins | ||||||||
|---|---|---|---|---|---|---|---|---|
This protein-related article is a stub.
|
| Genetics and Genomics | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| Overview of tumors, cancer and oncology (C00–D48, 140–239) | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| Serine protease inhibitors | ||||||
|---|---|---|---|---|---|---|
This serine protease inhibitor-related article is a stub.
|
Sponsored Health Resource
W8MD Weight Loss, Sleep & MedSpa
Looking for physician-supervised weight loss, semaglutide, tirzepatide, or GLP-1 receptor agonist options? W8MD helps eligible patients in New York City, Brooklyn, New Jersey, Connecticut, Pennsylvania, Delaware, and greater Philadelphia with medical weight loss, sleep medicine, and long-term maintenance support.
GLP-1 specials: Affordable GLP-1 injections NYC and Philadelphia starting from $29.99/week and up for semaglutide with insurance accepted for qualifying visits, and $45/week and up for tirzepatide with insurance accepted for qualifying visits. Self-pay options start from $59.99/week and up for semaglutide and $69.99/week and up for tirzepatide.
- Medical weight loss NYC
- Affordable GLP-1 injections NYC
- Budget GLP-1 weight loss shots Philadelphia
- New Jersey medical weight loss
- NYC medical weight loss blog
- Philadelphia weight loss blog
- Sleep medicine and sleep apnea services
- W8MD MedSpa and wellness
Book a W8MD appointment · View GLP-1 specials
Paid promotional message. Eligibility, pricing, insurance coverage, medication availability, and results vary. Medical evaluation required.
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
