NV-5138
NV-5138 is an experimental drug currently under development for the treatment of Major Depressive Disorder (MDD) and other Mental Disorders. It is being developed by the biopharmaceutical company Naurex, a subsidiary of Allergan.
Mechanism of Action[edit | edit source]
NV-5138 acts as a selective mTORC1 activator. mTORC1, or mechanistic target of rapamycin complex 1, is a protein complex that controls protein synthesis and has been implicated in a variety of diseases, including depression. By activating mTORC1, NV-5138 is thought to stimulate the synthesis of proteins that are necessary for the formation of new synaptic connections in the brain, a process known as synaptogenesis. This is believed to result in an antidepressant effect.
Clinical Trials[edit | edit source]
NV-5138 has undergone Phase 1 Clinical Trials to evaluate its safety, tolerability, and pharmacokinetics in healthy volunteers. The results of these trials have not yet been published. Phase 2 trials are planned to further evaluate the drug's efficacy and safety in patients with MDD.
Potential Advantages[edit | edit source]
NV-5138 has several potential advantages over existing treatments for MDD. Firstly, it has a novel mechanism of action, which may make it effective in patients who have not responded to other treatments. Secondly, it is taken orally, which may make it more convenient than treatments that require injection. Finally, preliminary data suggest that it may have a rapid onset of action, potentially providing relief from depressive symptoms within hours or days rather than weeks.
Potential Disadvantages[edit | edit source]
As with any experimental drug, there are potential disadvantages and risks associated with NV-5138. These include the possibility of unknown side effects, the potential for drug interactions, and the risk that the drug may not be effective in treating MDD. Furthermore, the drug's long-term safety profile has not yet been established.
See Also[edit | edit source]
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