NV-5138
NV-5138 is an experimental drug currently under development for the treatment of Major Depressive Disorder (MDD) and other Mental Disorders. It is being developed by the biopharmaceutical company Naurex, a subsidiary of Allergan.
Mechanism of Action[edit | edit source]
NV-5138 acts as a selective mTORC1 activator. mTORC1, or mechanistic target of rapamycin complex 1, is a protein complex that controls protein synthesis and has been implicated in a variety of diseases, including depression. By activating mTORC1, NV-5138 is thought to stimulate the synthesis of proteins that are necessary for the formation of new synaptic connections in the brain, a process known as synaptogenesis. This is believed to result in an antidepressant effect.
Clinical Trials[edit | edit source]
NV-5138 has undergone Phase 1 Clinical Trials to evaluate its safety, tolerability, and pharmacokinetics in healthy volunteers. The results of these trials have not yet been published. Phase 2 trials are planned to further evaluate the drug's efficacy and safety in patients with MDD.
Potential Advantages[edit | edit source]
NV-5138 has several potential advantages over existing treatments for MDD. Firstly, it has a novel mechanism of action, which may make it effective in patients who have not responded to other treatments. Secondly, it is taken orally, which may make it more convenient than treatments that require injection. Finally, preliminary data suggest that it may have a rapid onset of action, potentially providing relief from depressive symptoms within hours or days rather than weeks.
Potential Disadvantages[edit | edit source]
As with any experimental drug, there are potential disadvantages and risks associated with NV-5138. These include the possibility of unknown side effects, the potential for drug interactions, and the risk that the drug may not be effective in treating MDD. Furthermore, the drug's long-term safety profile has not yet been established.
See Also[edit | edit source]
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Template:Experimental drugs Template:Depression
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Usage[edit source]The Template:They is used in place of gender-specific pronouns when the gender of the person referred to is unknown, irrelevant, or when the person prefers they/them pronouns. It is also used when referring to a generic or hypothetical person whose gender is not specified. To use the template, editors simply include Template loop detected: Template:They in the text where they would normally use a pronoun. The template then renders as "they" in the published article. Background[edit source]The use of "they" as a singular pronoun has a long history in the English language. However, its use has become more prominent and politically significant in recent years due to growing awareness and acceptance of non-binary and genderqueer identities. The Template:They is part of a suite of templates designed to promote gender-neutral language on Wikipedia. Other related templates include Template:Them and Template:Their, which render as "them" and "their" respectively. Controversy[edit source]While the use of Template:They is generally accepted within the Wikipedia community, it has been the subject of some controversy. Critics argue that the use of "they" as a singular pronoun can be grammatically confusing or incorrect. However, proponents argue that it is a necessary and respectful way to acknowledge non-binary and genderqueer individuals. See also[edit source]
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Usage[edit source]To use the Template:Them, editors simply include the code Template loop detected: Template:Them at the appropriate place in the article. This will automatically insert the standardized text or formatting defined in the template. Customization[edit source]While the Template:Them provides a standard format, it can often be customized to better fit the specific needs of an article. This is typically done through the use of parameters, which are defined in the template code and can be adjusted in each individual use of the template. Benefits[edit source]The use of templates like Template:Them offers several benefits. It helps to maintain consistency across articles, making it easier for readers to navigate and understand the content. It also simplifies the editing process, as editors can insert a large amount of standardized text or formatting with a single line of code. Limitations[edit source]Despite their benefits, templates also have some limitations. They can be complex to create and edit, particularly for those unfamiliar with mediawiki code. They can also make the source code of an article more difficult to read and understand. See also[edit source]
Usage[edit source]The Template:They is used in place of gender-specific pronouns when the gender of the person referred to is unknown, irrelevant, or when the person prefers they/them pronouns. It is also used when referring to a generic or hypothetical person whose gender is not specified. To use the template, editors simply include Template loop detected: Template:They in the text where they would normally use a pronoun. The template then renders as "they" in the published article. Background[edit source]The use of "they" as a singular pronoun has a long history in the English language. However, its use has become more prominent and politically significant in recent years due to growing awareness and acceptance of non-binary and genderqueer identities. The Template:They is part of a suite of templates designed to promote gender-neutral language on Wikipedia. Other related templates include Template:Them and Template:Their, which render as "them" and "their" respectively. Controversy[edit source]While the use of Template:They is generally accepted within the Wikipedia community, it has been the subject of some controversy. Critics argue that the use of "they" as a singular pronoun can be grammatically confusing or incorrect. However, proponents argue that it is a necessary and respectful way to acknowledge non-binary and genderqueer individuals. See also[edit source]
experiences issues;
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