Ro 2-7239

A detailed overview of the compound Ro 2-7239

Ro 2-7239 is a chemical compound that has been studied for its potential pharmacological effects. It is part of a class of compounds known as benzodiazepines, which are known for their effects on the central nervous system. Ro 2-7239 has been investigated primarily for its anxiolytic and sedative properties.

Chemical Structure and Properties

Ro 2-7239 is a derivative of the benzodiazepine class, characterized by a benzene ring fused to a diazepine ring. The specific chemical structure of Ro 2-7239 includes various functional groups that contribute to its pharmacological activity. The compound's molecular formula is C16H13ClN2O, and it has a molar mass of 284.74 g/mol.

Pharmacodynamics

Ro 2-7239 acts primarily on the gamma-aminobutyric acid (GABA) receptor, which is the main inhibitory neurotransmitter in the central nervous system. By binding to the GABA_A receptor, Ro 2-7239 enhances the effect of GABA, leading to increased neuronal inhibition. This results in the compound's anxiolytic and sedative effects.

Pharmacokinetics

The absorption, distribution, metabolism, and excretion (ADME) of Ro 2-7239 have been studied in various animal models. The compound is well-absorbed when administered orally, and it is distributed throughout the body, crossing the blood-brain barrier to exert its effects on the central nervous system. Ro 2-7239 is metabolized primarily in the liver, and its metabolites are excreted via the kidneys.

Clinical Studies

Although Ro 2-7239 has shown promise in preclinical studies, its clinical development has been limited. Initial trials focused on its potential use as an anxiolytic agent, but further research is needed to fully understand its efficacy and safety profile in humans.

Potential Applications

Ro 2-7239 may have potential applications in the treatment of anxiety disorders, insomnia, and other conditions where benzodiazepines are typically used. However, due to the risk of dependence and other side effects associated with benzodiazepines, careful consideration and further research are necessary.

Safety and Side Effects

As with other benzodiazepines, Ro 2-7239 may cause side effects such as drowsiness, dizziness, and impaired coordination. Long-term use can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation. It is important to use such compounds under medical supervision.

Also see

• Benzodiazepine
• GABA receptor
• Anxiolytic
• Sedative

Benzodiazipines

• Alprazolam
• Chlordiazepoxide
• Diazepam (Oral)
• Estazolam
• Flurazepam
• Lorazepam
• Midazolam
• Oxazepam
• Quazepam
• Temazepam
• Triazolam

Anticonvulsants Drugs

• Clobazam
• Clonazepam
• Clorazepate
• Diazepam (Intravenous)

Drug class for Ro 2-7239

Anticonvulsants, and Benzodiazepines]