Salicylate sensitivity

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Salicylate sensitivity
Salicylic-acid-skeletal.svg
Synonyms N/A
Pronounce N/A
Specialty N/A
Symptoms Asthma, rhinitis, urticaria, angioedema, abdominal pain, diarrhea
Complications N/A
Onset Variable, often within hours of exposure
Duration Variable, symptoms may persist as long as exposure continues
Types N/A
Causes Salicylates in food, medication, and cosmetics
Risks Asthma, chronic rhinosinusitis, nasal polyps
Diagnosis Clinical history, elimination diet, oral challenge test
Differential diagnosis Aspirin-exacerbated respiratory disease, food allergy, intolerance
Prevention Avoidance of salicylate-containing substances
Treatment Antihistamines, leukotriene receptor antagonists, corticosteroids
Medication N/A
Prognosis Good with avoidance of triggers
Frequency Unknown, varies by population
Deaths N/A


Salicylate sensitivity is a condition in which individuals experience adverse reactions to salicylates, a group of chemicals found naturally in many plants and used in various medications, preservatives, and flavorings. Salicylates are present in foods, beverages, and personal care products, and they are also a key ingredient in aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs).

Symptoms[edit | edit source]

Individuals with salicylate sensitivity may experience a range of symptoms, which can vary in severity. Common symptoms include:

Causes[edit | edit source]

The exact cause of salicylate sensitivity is not well understood. It is believed to be related to the body's inability to properly metabolize salicylates. This condition is different from a salicylate allergy, which involves the immune system. Salicylate sensitivity is more common in individuals with asthma, chronic rhinosinusitis, and nasal polyps.

Diagnosis[edit | edit source]

Diagnosing salicylate sensitivity can be challenging due to the wide range of symptoms and their overlap with other conditions. A diagnosis is typically made based on a patient's medical history, symptom diary, and response to a low-salicylate diet. In some cases, an elimination diet followed by a controlled reintroduction of salicylates may be used to confirm the diagnosis.

Management[edit | edit source]

The primary treatment for salicylate sensitivity is avoiding foods, medications, and products that contain salicylates. This may involve:

  • Following a low-salicylate diet
  • Reading labels on food and personal care products
  • Consulting with a healthcare provider before taking medications

Foods High in Salicylates[edit | edit source]

Some foods that are high in salicylates and may need to be avoided include:

Related Conditions[edit | edit source]

Salicylate sensitivity is often associated with other conditions, such as:

See Also[edit | edit source]

References[edit | edit source]



External Links[edit | edit source]

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Contributors: Prab R. Tumpati, MD