Septo-optic dysplasia
| Septo-optic dysplasia | |
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| The optic nerve is underdeveloped in this condition | |
| Synonyms | de Morsier syndrome[1][2]
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| Specialty | ophthalmology
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Also called Septo-optic dysplasia (SOD), it is a rare disorder characterized by abnormal development of the optic disk, pituitary deficiencies, and often agenesis (absence) of the septum pellucidum (the part of the brain that separates the anterior horns or the lateral ventricles of the brain).
Signs and symptoms[edit]
Symptoms may include blindness in one or both eyes, pupil dilation in response to light, nystagmus (a rapid, involuntary to-and-fro movement of the eyes), inward and outward deviation of the eyes, hypotonia (low muscle tone), and hormonal problems. Seizures may also occur. In a few cases, jaundice (prolonged yellow skin discoloration) may occur at birth. Intellectual problems vary in severity among individuals. While some children with SOD have normal intelligence, others have learning disabilities. Most, however, are developmentally delayed due to vision impairment or neurological problems.
Treatment[edit]
Treatment for SOD is symptomatic. Hormone deficiencies may be treated with hormone replacement therapy. The optical problems associated with SOD are generally not treatable. Vision, physical, and occupational therapies may be required.
Prognosis[edit]
The prognosis for individuals with SOD varies according to the presence and severity of symptoms.
External links[edit]
| Congenital malformations and deformations of nervous system | ||||||||||
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| Genetic disorders relating to deficiencies of transcription factor or coregulators | ||||||||||||||||||||||||||||||||||
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Septo-optic dysplasia
- ↑ synd/2548 at Who Named It?
- ↑ G. de Morsier. Études sur les dysraphies, crânioencéphaliques. III. Agénésie du septum palludicum avec malformation du tractus optique. La dysplasie septo-optique. Schweizer Archiv für Neurologie und Psychiatrie, Zurich, 1956, 77: 267-292.
