Sertoli cell tumour

Sertoli cell tumour is a type of testicular cancer that originates from the Sertoli cells in the testis. These cells are part of the seminiferous tubules and play a crucial role in spermatogenesis, the process of sperm production.

Overview

Sertoli cell tumours are rare and account for less than 1% of all testicular cancers. They are usually benign, but in rare cases, they can be malignant. The tumours are often discovered during a physical examination or through imaging tests. Symptoms may include a lump in the testicle, testicular pain or discomfort, and in some cases, gynecomastia (enlargement of male breasts) due to hormonal changes.

Diagnosis

The diagnosis of a Sertoli cell tumour is typically confirmed through a biopsy, where a small sample of the tumour is removed and examined under a microscope. Immunohistochemistry is often used to differentiate Sertoli cell tumours from other types of testicular tumours.

Treatment

The primary treatment for Sertoli cell tumours is surgical removal of the tumour, known as orchiectomy. In some cases, additional treatments such as radiation therapy or chemotherapy may be recommended, particularly if the tumour is malignant or if it has spread to other parts of the body.

Prognosis

The prognosis for individuals with Sertoli cell tumours is generally good, particularly if the tumour is detected early and is benign. However, malignant tumours or those that have spread can be more challenging to treat and may have a poorer prognosis.

See also

• Testicular cancer
• Sertoli cells
• Spermatogenesis
• Orchiectomy