Acute cortical necrosis

From WikiMD's WELLNESSPEDIA

Acute kidney injury caused by ischemic necrosis of the renal cortex. Renal cortex is very sensitive to hypoxia.

Kidney – acute cortical necrosis
Kidney – acute cortical necrosis

Causes[edit]

Acute cortical necrosis can be caused many factors including vascular disease, infections, autoimmune problems, trauma, alcohol, pregnancy, to name a few and include the following:

  • Acute tubular necrosis
  • Autoimmune kidney disease
  • Blood clot from cholesterol
  • Decreased blood flow due to very low blood pressure due to burns, dehydration, hemorrhage, injury, septic shock, serious illness, or surgery
  • Disorders that cause clotting within the kidney blood vessels
  • Infections that directly injure the kidney, such as acute pyelonephritis or septicemia
  • Pregnancy complications, including placenta abruption or placenta previa
  • Urinary tract blockage
  • Illicit drugs such as cocaine and heroine
  • Medicines including non-steroidal anti-inflammatory drugs (NSAIDs), certain antibiotics and blood pressure medicines, intravenous contrast (dye), some cancer and HIV drugs
Renal cortical infarction showing coagulative necrosis
Renal cortical infarction showing coagulative necrosis

Symptoms[edit]

  • Bloody stools
  • Breath odor and metallic taste in the mouth
  • Bruising easily
  • Changes in mental status or mood
  • Decreased appetite
  • Fatigue or slow sluggish movements
  • Flank pain (between the ribs and hips)
  • High blood pressure  
  • Nausea or vomiting, may last for days
  • Swelling due to the body keeping in fluid
  • Urination changes, such as little or no urine

Kidney ultrasound
Kidney ultrasound

Investigations[edit]

Treatment[edit]

Treatment depends on the cause and rapid reversal of the cause can lead to full recovery.

Alternative Names[edit]

  • Diffuse bilateral renal cortical necrosis (BRCN)
  • Diffuse cortical necrosis
  • Acute cortical necrosis
  • Acute kidney failure with acute cortical necrosis
Health science - Medicine - Nephrology - edit
Diseases of the glomerulus
Lupus nephritis | Post-infectious glomerulonephritis | Minimal change disease | Focal segmental glomerulosclerosis | Diabetic nephropathy
Diseases of the proximal convoluted tubules
Fanconi syndrome (Type II renal tubular acidosis) | renal cell carcinoma
Diseases of the distal convoluted tubules
pseudohypoaldosteronism (Type IV renal tubular acidosis)
Diseases of the collecting duct
Type I renal tubular acidosis
Tumours of the kidney
renal cell carcinoma | Wilms' tumour (children)
Diseases of the renal vasculature
renal artery stenosis | vasculitis | atheroembolic disease
Tubulointerstitial diseases of the kidney
Drug-induced interstitial nephritis | Obstructive nephropathy | Radiation nephritis | Reflux nephropathy | Sarcoidosis
Genetic diseases of the kidney/syndromes associated with kidney dysfunction
Alport syndrome | Polycystic kidney disease | Wilms' tumour (children)

von Hippel-Lindau syndrome | Hereditary papillary renal carcinoma | Birt-Hogg-Dube syndrome | Hereditary renal carcinoma

Chronic kidney disease and related conditions

Chronic Kidney Disease

Anemia in CKD | Causes of CKD | CKD Overview | CKD Tests and Diagnosis | Diabetic Kidney Disease | Eating Right for CKD | High Blood Pressure and Kidney Disease | Managing CKD | Mineral and Bone Disorder in CKD | Nutrition for Advanced CKD in Adults | Preventing CKD | Quick Reference on UACR & GFR

Kidney Failure

Eating and Nutrition for Hemodialysis | Financial Help for Treatment of Kidney Failure | Hemodialysis | Kidney Failure | Kidney Transplant | Peritoneal Dialysis

Other Kidney Topics

Acquired Cystic Kidney Disease | Amyloidosis and Kidney Disease | Diabetes Insipidus | Ectopic Kidney | Glomerular Diseases | Goodpasture Syndrome | Henoch-Schönlein Purpura | IgA Nephropathy | Kidney Dysplasia | Kidney Infection (Pyelonephritis) | Kidney Stones | Lupus Nephritis | Medullary Sponge Kidney | Nephrotic Syndrome in Adults | Pain Medicine and Kidney Damage | Polycystic Kidney Disease (PKD) | Renal Artery Stenosis | Renal Tubular Acidosis | Simple Kidney Cysts | Solitary Kidney | Your Kidneys and How They Work | Your Urinary Tract and How It Works

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