Atazanavir sulfate

Atazanavir sulfate is an antiretroviral medication used in the treatment of human immunodeficiency virus (HIV) infections. It is a type of medication known as a protease inhibitor, which works by blocking the action of an enzyme called protease that HIV needs to multiply in the body.

Pharmacology[edit | edit source]

Atazanavir sulfate is a protease inhibitor that binds to the active site of HIV-1 protease, preventing the cleavage of viral polyproteins and thereby inhibiting viral replication. It is often used in combination with other antiretroviral medications as part of an antiretroviral therapy (ART) regimen.

Clinical Use[edit | edit source]

Atazanavir sulfate is indicated for use in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and children aged 6 years and older. It is often used as part of a regimen for patients who have not previously received antiretroviral treatment, as well as for patients who have previously received treatment and have demonstrated resistance to other protease inhibitors.

Side Effects[edit | edit source]

Common side effects of atazanavir sulfate include jaundice, rash, nausea, headache, and abdominal pain. Serious side effects can include severe skin reactions, liver problems, and changes in heart rhythm.

Drug Interactions[edit | edit source]

Atazanavir sulfate can interact with a number of other medications, including certain other antiretroviral medications, antacids, H2 blockers, proton pump inhibitors, and certain statins. It is important for patients to inform their healthcare provider of all medications they are taking before starting treatment with atazanavir sulfate.