DY-131
DY-131 is a synthetic compound that acts as a selective modulator of the estrogen-related receptor alpha (ERRα). It is primarily used in research settings to study the role of ERRα in various biological processes, including metabolism, cancer, and cardiovascular function.
Chemical Structure and Properties[edit | edit source]
DY-131 is a small molecule with a specific chemical structure that allows it to interact selectively with ERRα. The compound's structure is designed to fit into the ligand-binding domain of ERRα, modulating its activity. The precise IUPAC name and molecular formula of DY-131 are crucial for understanding its chemical properties and interactions.
Mechanism of Action[edit | edit source]
DY-131 functions as an agonist or antagonist of ERRα, depending on the cellular context. By binding to ERRα, DY-131 can influence the transcription of genes regulated by this receptor. ERRα is an orphan nuclear receptor, meaning it does not have a known endogenous ligand, making synthetic modulators like DY-131 valuable tools for research.
Biological Significance[edit | edit source]
ERRα is involved in the regulation of energy metabolism, mitochondrial function, and cellular growth. It is expressed in various tissues, including the heart, skeletal muscle, and liver. DY-131 has been used to elucidate the role of ERRα in these tissues, providing insights into its potential as a therapeutic target for metabolic disorders and cancer.
Research Applications[edit | edit source]
DY-131 is utilized in laboratory studies to:
- Investigate the role of ERRα in metabolic pathways and energy homeostasis.
- Explore the potential of ERRα as a target in oncology, particularly in breast and prostate cancers.
- Study the effects of ERRα modulation on cardiovascular health.
Safety and Handling[edit | edit source]
As with many research chemicals, DY-131 should be handled with care in a laboratory setting. Proper safety protocols, including the use of personal protective equipment (PPE) and adherence to material safety data sheets (MSDS), are essential to ensure safe handling.
Also see[edit | edit source]
- Estrogen-related receptor alpha
- Nuclear receptor
- Selective estrogen receptor modulator
- Metabolic disorder
- Cancer research
References[edit | edit source]
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