Dextromethorphan/bupropion

Dextromethorphan/bupropion is a combination drug used for the treatment of MDD and ADHD. It is a combination of Dextromethorphan, an NMDA receptor antagonist, and Bupropion, a norepinephrine-dopamine reuptake inhibitor.

Pharmacology

Dextromethorphan is a NMDA receptor antagonist and sigma-1 receptor agonist. It also has serotonin reuptake inhibiting properties. Bupropion is a norepinephrine-dopamine reuptake inhibitor and a nicotinic antagonist. The combination of these two drugs is believed to have a synergistic effect in treating MDD and ADHD.

Clinical Use

Dextromethorphan/bupropion is used for the treatment of MDD and ADHD. It is also being investigated for its potential use in treating neuropathic pain and obesity.

Side Effects

Common side effects of dextromethorphan/bupropion include nausea, dry mouth, insomnia, constipation, dizziness, and sweating. Serious side effects may include seizures, mania, hypertension, and allergic reactions.

See Also

• Dextromethorphan
• Bupropion
• Major depressive disorder
• Attention deficit hyperactivity disorder

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The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone

Dextromethorphan/bupropion

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  Dextromethorphan chemical structure
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  Bupropion chemical structure
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  Antidepressant efficacy of dextromethorphan and bupropion (Auvelity) versus placebo in the GEMINI trial