Doege–Potter syndrome
Doege–Potter Syndrome[edit | edit source]
Doege–Potter syndrome is a rare paraneoplastic syndrome characterized by hypoglycemia associated with solitary fibrous tumors, most commonly solitary fibrous tumors of the pleura. This condition is named after Karl Doege and Roy Potter, who first described the syndrome in the 1930s.
Pathophysiology[edit | edit source]
The hypoglycemia in Doege–Potter syndrome is caused by the production of insulin-like growth factor 2 (IGF2) by the tumor. IGF2 is a hormone similar in molecular structure to insulin, and it can lower blood glucose levels by increasing glucose uptake into cells and inhibiting glucose production by the liver. The overproduction of IGF2 by the tumor leads to persistent hypoglycemia, which can be severe and symptomatic.
Clinical Presentation[edit | edit source]
Patients with Doege–Potter syndrome typically present with symptoms of hypoglycemia, which may include dizziness, sweating, confusion, seizures, and even loss of consciousness. These symptoms are often episodic and may be exacerbated by fasting or physical exertion.
Diagnosis[edit | edit source]
The diagnosis of Doege–Potter syndrome is based on the clinical presentation of hypoglycemia in conjunction with the presence of a solitary fibrous tumor. Imaging studies such as computed tomography (CT) or magnetic resonance imaging (MRI) are used to identify the tumor. Biochemical tests may reveal low blood glucose levels and elevated levels of IGF2.
Treatment[edit | edit source]
The primary treatment for Doege–Potter syndrome is the surgical resection of the tumor. Removal of the tumor typically resolves the hypoglycemia. In cases where the tumor is not resectable, medical management of hypoglycemia may be necessary, which can include dietary modifications and medications to increase blood glucose levels.
Prognosis[edit | edit source]
The prognosis for patients with Doege–Potter syndrome is generally favorable if the tumor can be completely resected. However, the prognosis may be poorer if the tumor is malignant or if complete resection is not possible.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
