Adapalene and benzoyl peroxide
(Redirected from Epiduo)
What is Adapalene and benzoyl peroxide?[edit | edit source]
- Adapalene and benzoyl peroxide (Epiduo) is a combination of adapalene, a retinoid, and benzoyl peroxide, and is used for the topical treatment of acne vulgaris.
What are the uses of this medicine?[edit | edit source]
- Adapalene and benzoyl peroxide (Epiduo) is a prescription medicine for skin use only (topical) used to treat acne vulgaris in people 9 years of age and older.
- Acne vulgaris is a condition in which the skin has blackheads, whiteheads and pimples.
How does this medicine work?[edit | edit source]
Adapalene:
- Adapalene binds to specific retinoic acid nuclear receptors but does not bind to cytosolic receptor protein.
- Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization and inflammatory processes.
- However, the significance of these findings with regard to the mechanism of action of adapalene for the treatment of acne is unknown.
Benzoyl peroxide:
- Benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects.
Who Should Not Use this medicine ?[edit | edit source]
- This medicine have no usage limitations.
What drug interactions can this medicine cause?[edit | edit source]
- Concomitant topical acne therapy should be used with caution because a possible cumulative irritancy effect may occur, especially with the use of peeling, desquamating, or abrasive agents.
Is this medicine FDA approved?[edit | edit source]
- Initial U.S. Approval: 2008
How should this medicine be used?[edit | edit source]
Recommended dosage:
- Apply a thin film of adapalene and benzoyl peroxide gel 0.1% / 2.5% to affected areas of the face and/or trunk once daily after washing.
- Use a pea-sized amount for each area of the face (e.g., forehead, chin, each cheek).
Administration:
- Adapalene and benzoyl peroxide gel 0.1% / 2.5% is for skin use only. Do not use adapalene and benzoyl peroxide gel 0.1% / 2.5% in or on your mouth, eyes, or vagina.
- Apply adapalene and benzoyl peroxide gel 0.1% / 2.5% 1 time a day.
- Do not use more adapalene and benzoyl peroxide gel 0.1% / 2.5% than you need to cover the treatment area.
- Using too much adapalene and benzoyl peroxide gel 0.1% / 2.5% or using it more than 1 time a day may increase your chance of skin irritation.
What are the dosage forms and brand names of this medicine?[edit | edit source]
This medicine is available in fallowing doasage form:
- As adapalene and benzoyl peroxide gel 0.1% / 2.5% contains 1 mg (0.1%) adapalene and 25 mg (2.5%) benzoyl peroxide.
This medicine is available in fallowing brand namesː
- Epiduo
What side effects can this medication cause?[edit | edit source]
The most common side effects of this medicine include:
- dry skin
- contact dermatitis
- application site burning
- application site irritation
- skin irritation
Adapalene and benzoyl peroxide gel 0.1% / 2.5% may cause serious side effects including:
- Local skin reactions
What special precautions should I follow?[edit | edit source]
- Avoid exposure to sunlight and sunlamps. Wear sunscreen when sun exposure cannot be avoided. Erythema, scaling, dryness, stinging/burning, irritant and allergic contact dermatitis may occur with use of adapalene and benzoyl peroxide gel 0.1% / 2.5% and may necessitate discontinuation.
- Avoid concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have strong skin-drying effect and products with high concentrations of alcohol, astringents, spices, or limes).
What to do in case of emergency/overdose?[edit | edit source]
- In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.
- Overdose related information is also available online at poisonhelp.org/help.
- In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
Can this medicine be used in pregnancy?[edit | edit source]
- Pregnancy Category C.
- There are no well-controlled trials in pregnant women treated with adapalene and benzoyl peroxide gel 0.1% / 2.5%.
Can this medicine be used in children?[edit | edit source]
- It is not known if adapalene and benzoyl peroxide gel 0.1% / 2.5% is safe and effective in children younger than 9 years old.
What are the active and inactive ingredients in this medicine?[edit | edit source]
- Active ingredient: adapalene and benzoyl peroxide
- Inactive ingredients: carbopol 980, d-limonene, docusate sodium solution, edetate disodium, glycerin, poloxamer 182, polysorbate 80, propylene glycol, purified water, sodium hydroxide and sorbitan monooleate.
Who manufactures and distributes this medicine?[edit | edit source]
Manufactured by:
- TOLMAR Inc., Fort Collins, CO 80526 for
- Sandoz Inc., Princeton NJ
What should I know about storage and disposal of this medication?[edit | edit source]
- Store adapalene and benzoyl peroxide gel 0.1% / 2.5% at room temperature, 68° – 77° F (20° – 25° C)
- Keep adapalene and benzoyl peroxide gel 0.1% / 2.5% inside container and out of light and away from heat.
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