Guanidinium chloride
| Guanidinium chloride | |
|---|---|
| Guanidinium chloride.png | |
| Structural formula of guanidinium chloride | |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider ID | |
| UNII | |
| ChEBI | |
| ChEMBL | |
| Properties | |
| Chemical Formula | |
| Molar Mass | 95.53 g/mol |
| Appearance | White crystalline solid |
| Density | 1.354 g/cm3 |
| Melting Point | 182 °C |
| Boiling Point | |
| Hazards | |
| GHS Pictograms | [[File:|50px]] |
| GHS Signal Word | |
| GHS Hazard Statements | |
| NFPA 704 | [[File:|50px]] |
| References | |
Guanidinium chloride (also known as guanidine hydrochloride) is a chemical compound with the formula CH6ClN3. It is the chloride salt of guanidine.
Structure and Properties[edit]
Guanidinium chloride is a white crystalline solid that is highly soluble in water. It is composed of the guanidinium cation (C(NH2)3+) and the chloride anion (Cl-). The guanidinium ion is planar and exhibits resonance stabilization, which contributes to its stability.
Chemical Properties[edit]
Guanidinium chloride is a strong chaotropic agent, meaning it can disrupt the structure of water and proteins. It is often used in biochemistry to denature proteins by disrupting hydrogen bonds and hydrophobic interactions.
Applications[edit]
Guanidinium chloride has several important applications in the field of biochemistry and molecular biology.
Protein Denaturation[edit]
One of the primary uses of guanidinium chloride is in the denaturation of proteins. It is commonly used in protein purification protocols to unfold proteins, allowing for the removal of contaminants and the study of protein folding and stability.
RNA Isolation[edit]
Guanidinium chloride is also used in the isolation of RNA. It helps to lyse cells and inactivate RNase enzymes, which are responsible for degrading RNA. This makes it a crucial component in RNA extraction protocols.
DNA Extraction[edit]
In addition to RNA isolation, guanidinium chloride is used in DNA extraction procedures. It helps to solubilize cellular components and protect nucleic acids from degradation.
Safety and Handling[edit]
Guanidinium chloride should be handled with care, as it can be harmful if ingested or inhaled. It may cause irritation to the skin, eyes, and respiratory tract. Proper personal protective equipment (PPE) such as gloves and goggles should be worn when handling this compound.
See Also[edit]
External Links[edit]
- [Guanidinium chloride on PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Guanidinium-chloride)
- [Guanidinium chloride safety data sheet]
| Chemical compounds | ||||||
|---|---|---|---|---|---|---|
This chemical compound-related article is a stub.
|
| Biochemistry | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
This biochemistry related article is a stub.
|
Sponsored Health Resource
W8MD Weight Loss, Sleep & MedSpa
Looking for physician-supervised weight loss, semaglutide, tirzepatide, or GLP-1 receptor agonist options? W8MD helps eligible patients in New York City, Brooklyn, New Jersey, Connecticut, Pennsylvania, Delaware, and greater Philadelphia with medical weight loss, sleep medicine, and long-term maintenance support.
GLP-1 specials: Affordable GLP-1 injections NYC and Philadelphia starting from $29.99/week and up for semaglutide with insurance accepted for qualifying visits, and $45/week and up for tirzepatide with insurance accepted for qualifying visits. Self-pay options start from $59.99/week and up for semaglutide and $69.99/week and up for tirzepatide.
- Medical weight loss NYC
- Affordable GLP-1 injections NYC
- Budget GLP-1 weight loss shots Philadelphia
- New Jersey medical weight loss
- NYC medical weight loss blog
- Philadelphia weight loss blog
- Sleep medicine and sleep apnea services
- W8MD MedSpa and wellness
Book a W8MD appointment · View GLP-1 specials
Paid promotional message. Eligibility, pricing, insurance coverage, medication availability, and results vary. Medical evaluation required.
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
