PARG

Poly(ADP-ribose) glycohydrolase (PARG) is an enzyme that in humans is encoded by the PARG gene. PARG is involved in the poly(ADP-ribose) polymerase (PARP) pathway, which is responsible for the detection and repair of single-strand DNA breaks in the cell.

Function

PARG is responsible for the hydrolysis of poly(ADP-ribose) (PAR), a post-translational modification of proteins involved in the regulation of DNA repair, genomic stability, and programmed cell death. The enzyme catalyzes the removal of ADP-ribose units from PAR chains to restore the DNA structure and maintain genomic stability.

Clinical significance

Mutations in the PARG gene have been associated with various diseases, including cancer, neurodegenerative diseases, and inflammatory diseases. In cancer, PARG is often overexpressed, leading to increased PAR degradation and resistance to chemotherapy. In neurodegenerative and inflammatory diseases, PARG inhibition has been shown to reduce cell death and inflammation, respectively.

Research

PARG inhibitors are currently being researched as potential therapeutic agents for the treatment of cancer, neurodegenerative diseases, and inflammatory diseases. Early studies have shown promising results, but further research is needed to fully understand the therapeutic potential of PARG inhibition.

See also

• Poly(ADP-ribose) polymerase
• DNA repair
• Post-translational modification