Romazarit

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{{Drugbox | Verifiedfields = changed | verifiedrevid = 477002123 | IUPAC_name = (2R)-2-[[4-(2,4-dioxothiazolidin-3-yl)phenyl]methyl]-3-methylbutanoic acid | image = Romazarit_structure.png | width = 200 | CAS_number = 87679-37-6 | ATC_prefix = M01 | ATC_suffix = AX06 | PubChem = 65659 | ChemSpiderID = 59095 | UNII = 3F0I0T7Y6P | KEGG = D05792 | ChEMBL = 2103880 | C=15 | H=17 | N=1 | O=4 | S=1 | smiles = CC(C)C(C(=O)O)Cc1ccc(cc1)C2C(=O)NC(=O)S2 | StdInChI = 1S/C15H17NO4S/c1-8(2)12(15(18)19)7-10-3-5-11(6-4-10)9-13-14(17)16-15(20)21-13/h3-6,8,12H,7,9H2,1-2H3,(H,18,19)(H,16,17,20) | StdInChIKey = ZQZQYVZQXGQXQK-UHFFFAOYSA-N }}

Romazarit is a pharmaceutical compound that was investigated for its potential use in the treatment of rheumatoid arthritis. It belongs to a class of drugs known as disease-modifying antirheumatic drugs (DMARDs), which are used to slow the progression of rheumatoid arthritis and improve quality of life for patients.

Mechanism of Action[edit | edit source]

Romazarit is believed to exert its effects by modulating the immune response and reducing inflammation. The exact mechanism of action is not fully understood, but it is thought to involve the inhibition of certain cytokines and enzymes that play a role in the inflammatory process associated with rheumatoid arthritis.

Clinical Trials[edit | edit source]

Romazarit underwent several clinical trials to evaluate its efficacy and safety in patients with rheumatoid arthritis. Early studies suggested that Romazarit could reduce joint inflammation and slow disease progression. However, subsequent trials failed to demonstrate significant clinical benefits over existing treatments, leading to a decline in its development and use.

Side Effects[edit | edit source]

The side effects of Romazarit were similar to those of other DMARDs, including gastrointestinal disturbances, liver enzyme abnormalities, and potential hematological effects. Due to these side effects and the lack of superior efficacy, Romazarit was not widely adopted in clinical practice.

Current Status[edit | edit source]

As of the latest updates, Romazarit is not actively marketed or used in the treatment of rheumatoid arthritis. Research and development have shifted towards other more promising therapies that offer better efficacy and safety profiles.

Also see[edit | edit source]

Rheumatologic diseases[edit source]

Arthritis is often used to refer to any disorder that affects the joints. Rheumatic diseases usually affect joints, tendons, ligaments, bones, and muscles. Rheumatologic diseases usually affect joints, tendons, ligaments, bones, and muscles.

Connective Tissue Diseases
Rheumatology and Connective Tissue Diseases
Ankylosing spondylitis Arthritis
Arthritis and Rheumatic diseases Autoimmune diseases
Autoinflammatory diseases Behçet’s disease
Bursitis Giant cell arteritis
Gout Juvenile arthritis
Knee problems Lupus
Osteoarthritis Polymyalgia rheumatica
Psoriatic arthritis Reactive arthritis
Rheumatoid arthritis Scleroderma
Sjögren’s syndrome Systemic lupus erythematosus (Lupus)
Tendinitis Rheumatologic diseases

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Contributors: Prab R. Tumpati, MD