Valacyclovir hydrochloride
The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir.
Administration[edit | edit source]
Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes.
Mechanism of action[edit | edit source]
Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase.
How Acyclovir works better against HSV[edit | edit source]
The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicellla-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase.
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Contributors: Prab R. Tumpati, MD
