Aggrecanase
Aggrecanase is an enzyme in the connective tissue that plays an important role in the pathogenesis of arthritis and other connective tissue diseases.
Role of aggrecanases[edit | edit source]
Aggrecanases are extracellular proteolytic enzymes.
ADAMTS family[edit | edit source]
Aggrecanases belong to a group of protein cleaving enzymes called ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin Motifs) family.
Mechanism of action[edit | edit source]
Aggrecanases act on large proteoglycans known as aggrecans, which are components of connective tissues such as cartilage.
Clinical significance[edit | edit source]
The inappropriate activity of aggrecanase is a mechanism by which cartilage degradation occurs in diseases such as arthritis.
Types of aggrecanases[edit | edit source]
There are two forms of aggrecanase exist in humans: ADAMTS4 or aggrecanase-1[1] and ADAMTS5 or aggrecanase-2.
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
