Aggrecanase
Aggrecanase is an enzyme in the connective tissue that plays an important role in the pathogenesis of arthritis and other connective tissue diseases.
Role of aggrecanases[edit | edit source]
Aggrecanases are extracellular proteolytic enzymes.
ADAMTS family[edit | edit source]
Aggrecanases belong to a group of protein cleaving enzymes called ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin Motifs) family.
Mechanism of action[edit | edit source]
Aggrecanases act on large proteoglycans known as aggrecans, which are components of connective tissues such as cartilage.
Clinical significance[edit | edit source]
The inappropriate activity of aggrecanase is a mechanism by which cartilage degradation occurs in diseases such as arthritis.
Types of aggrecanases[edit | edit source]
There are two forms of aggrecanase exist in humans: ADAMTS4 or aggrecanase-1[1] and ADAMTS5 or aggrecanase-2.
External links[edit | edit source]
| Aggrecanase Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
