Carbarsone

Carbarsone

Carbarsone is a chemical compound used primarily in the treatment of amebiasis, a parasitic infection of the intestines caused by the amoeba Entamoeba histolytica. It is an organometallic compound that contains arsenic, and is classified as an antiprotozoal agent.

History

Carbarsone was first synthesized in the early 20th century as part of a broader effort to develop effective treatments for parasitic infections. Its antiprotozoal properties were discovered during in vitro testing, and it was subsequently developed into a drug for the treatment of amebiasis.

Pharmacology

Carbarsone acts by inhibiting the growth of E. histolytica, the amoeba responsible for causing amebiasis. It is believed to interfere with the amoeba's ability to metabolize glucose, which is essential for its survival and proliferation. However, the exact mechanism of action is not fully understood.

Medical uses

Carbarsone is used in the treatment of amebiasis, particularly in cases where the infection is localized in the intestines. It is administered orally, usually in the form of a tablet or capsule. The typical course of treatment lasts for several days, during which time the patient must also adhere to a specific diet to help clear the infection.

Side effects

Like all drugs, carbarsone can cause side effects. The most common side effects include nausea, vomiting, and abdominal pain. In rare cases, it can cause more serious side effects such as skin rash, fever, and jaundice. Due to its arsenic content, prolonged use of carbarsone can lead to arsenic poisoning.

See also

• Amebiasis
• Antiprotozoal agent
• Arsenic poisoning