GAS6

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Protein GAS6 PDB 1h30

GAS6

Growth Arrest-Specific 6 (GAS6) is a protein encoded by the GAS6 gene in humans. It is a member of the vitamin K-dependent protein family and plays a crucial role in various cellular processes. GAS6 is known to be involved in cell survival, proliferation, migration, and adhesion through its interaction with receptor tyrosine kinases known as TAM receptors.

Structure

GAS6 is a large protein consisting of multiple domains, including an N-terminal gamma-carboxyglutamic acid (Gla) domain, four epidermal growth factor (EGF)-like repeats, and two globular laminin G-like domains. The Gla domain is responsible for calcium-dependent binding to phospholipid membranes, while the EGF-like repeats are involved in receptor binding.

Function

GAS6 functions as a ligand for TAM receptors, which include Tyro3, Axl, and Mer. Binding of GAS6 to TAM receptors activates downstream signaling pathways that regulate cell survival, proliferation, and immune responses. GAS6-TAM signaling has been implicated in various physiological and pathological processes, including immune regulation, cancer progression, and neurodegeneration.

Clinical Relevance

Dysregulation of GAS6 expression or TAM receptor signaling has been associated with several diseases, including cancer, autoimmune disorders, and neurodegenerative conditions. Targeting the GAS6-TAM pathway has emerged as a potential therapeutic strategy for treating these diseases.