Interleukin 1 receptor, type II

Interleukin 1 receptor, type II (or IL1R2) is a protein that in humans is encoded by the IL1R2 gene. This protein is primarily associated with the immune system and plays a crucial role in inflammation and immune response.

Structure[edit | edit source]

The IL1R2 protein is a member of the interleukin 1 receptor family. This receptor specifically binds to interleukin 1 (IL1) and is one of the two receptors that can bind this cytokine. The other receptor that can bind IL1 is interleukin 1 receptor, type I (IL1R1).

Function[edit | edit source]

IL1R2 acts as a decoy receptor that inhibits the activity of its ligand, IL1. By doing so, it reduces the inflammatory and immune responses mediated by IL1. This is important in the regulation of immune response and inflammation, as excessive or prolonged inflammation can lead to tissue damage and disease.

Clinical significance[edit | edit source]

Alterations in the function or expression of IL1R2 have been associated with various diseases, including rheumatoid arthritis, asthma, and cancer. For example, increased expression of IL1R2 has been observed in the synovial fluid of patients with rheumatoid arthritis, suggesting a role for this receptor in the pathogenesis of this disease.