Levine–Crichley syndrome

Levine–Crichley syndrome is a rare neurological disorder characterized by intellectual disability, seizures, and skin abnormalities. It was first described by American neurologist Norman Levine and British neurologist Charles Crichley in the mid-20th century.

Symptoms and Signs

The primary symptoms of Levine–Crichley syndrome include intellectual disability, seizures, and skin abnormalities. The intellectual disability can range from mild to severe, and the seizures can vary in frequency and intensity. The skin abnormalities typically involve hyperpigmentation, or darkening of the skin, and hypopigmentation, or lightening of the skin.

Causes

The exact cause of Levine–Crichley syndrome is unknown. However, it is believed to be a genetic disorder, as it often runs in families. The specific gene or genes involved have not yet been identified.

Diagnosis

Diagnosis of Levine–Crichley syndrome is based on the presence of the characteristic symptoms and a family history of the disorder. Genetic testing may also be used to confirm the diagnosis, although the specific gene or genes involved have not yet been identified.

Treatment

There is currently no cure for Levine–Crichley syndrome. Treatment is focused on managing the symptoms and improving the quality of life for individuals with the disorder. This may include antiepileptic drugs to control seizures, physical therapy to improve motor skills, and special education programs to address intellectual disability.

Prognosis

The prognosis for individuals with Levine–Crichley syndrome varies depending on the severity of the symptoms. With appropriate treatment and support, many individuals with the disorder are able to lead fulfilling lives.

See Also

• List of neurological disorders
• Genetic disorder
• Intellectual disability
• Seizure

NIH genetic and rare disease info

• NIH info on Levine–Crichley syndrome

Levine–Crichley syndrome is a rare disease.

Levine–Crichley syndrome Resources
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