Limbus

Limbus is a border or edge that is often referred to in medical terminology. In ophthalmology, the limbus is the border between the cornea and the sclera. The limbus is a crucial area of the eye as it is responsible for the regeneration of the cornea.

Anatomy

The limbus is located at the junction of the cornea and the sclera. It is a complex structure that is composed of several different tissues. The limbus contains the corneal epithelial stem cells which are essential for the maintenance and repair of the corneal surface.

Function

The primary function of the limbus is to act as a barrier to prevent the invasion of the conjunctival epithelial cells onto the cornea. It also plays a crucial role in the maintenance of the corneal transparency by preventing the vascularization of the cornea.

Clinical significance

Damage to the limbus can lead to a condition known as limbal stem cell deficiency (LSCD). This condition can result in pain, loss of vision, and may require a limbal stem cell transplantation for treatment.

See also

• Cornea
• Sclera
• Limbal stem cell deficiency
• Limbal stem cell transplantation

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