Luminal b breast carcinoma

A biologic subset of breast cancer defined by low to moderate expression of genes characteristic of luminal epithelial cells including estrogen receptor (er), and high expression of ggh, laptm4b, and ccne1. This subtype of breast cancer is associated with a good prognosis, although not as favorable as the luminal a subtype.

Breast cancer subtypes

There are four main female breast cancer subtypes, including the following in order of prevalence:

• HR+/HER2- ("Luminal A")
• HR-/HER2- ("Triple Negative")
• HR+/HER2+ ("Luminal B")
• HR-/HER2+ ("HER2-enriched")

Abbreviations

• HR stands for hormone receptor.
• HR+ means that tumor cells have receptors for the hormones estrogen or progesterone, which can promote the growth of HR+ tumors.
• HER2 stands for human epidermal growth factor receptor 2.
• HER2+ means that tumor cells make high levels of a protein called HER2/neu, which has been shown to be associated with certain aggressive types of breast cancer.

At a Glance

Age-Adjusted Rate of New Breast Cases per 100,000 Women, SEER 21 2013–2017

Subtype	New Cases
HR+/HER2-	87.0
HR-/HER2-	13.0
HR+/HER2+	13.3
HR-/HER2+	5.5
Unknown	9.7
Total	128.5

When all subtypes are combined, female breast cancer is fairly common.

Luminal b breast carcinoma Resources
Latest articles Most recent articles Ongoing trials	Wikipedia