Seractide
Seractide is a synthetic form of adrenocorticotropic hormone (ACTH) used primarily in the diagnosis and treatment of certain medical conditions related to the adrenal glands. It is a polypeptide hormone that stimulates the adrenal cortex to secrete corticosteroids, which are crucial for various physiological functions, including stress response, immune response, and regulation of inflammation, metabolism, and electrolyte balance.
Pharmacology[edit | edit source]
Seractide acts by binding to specific receptors on the surface of adrenal cortex cells, leading to the activation of adenylate cyclase and an increase in intracellular cyclic AMP (cAMP). This cascade of events results in the synthesis and release of corticosteroids, including cortisol, from the adrenal glands.
Clinical Uses[edit | edit source]
Seractide is used in the following clinical scenarios:
- Diagnosis of Adrenal Insufficiency: It is used in the ACTH stimulation test to assess the functional capacity of the adrenal glands. This test helps in diagnosing conditions such as Addison's disease and secondary adrenal insufficiency.
- Treatment of Infantile Spasms: Seractide may be used in the management of infantile spasms, a type of epilepsy in infants, due to its ability to modulate the release of corticosteroids.
Administration[edit | edit source]
Seractide is typically administered via intramuscular injection. The dosage and duration of treatment depend on the specific condition being treated and the patient's response to therapy.
Side Effects[edit | edit source]
Common side effects of Seractide include:
- Weight gain
- Edema
- Hypertension
- Hyperglycemia
- Increased risk of infection
Long-term use can lead to more serious side effects such as osteoporosis, peptic ulcers, and adrenal suppression.
Contraindications[edit | edit source]
Seractide is contraindicated in patients with:
- Hypersensitivity to ACTH or any component of the formulation
- Systemic fungal infections
- Uncontrolled hypertension
Also see[edit | edit source]
References[edit | edit source]
- [1] Medical Textbook on Endocrinology
- [2] Clinical Pharmacology Journal
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