Technetium (99mTc) nofetumomab merpentan

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Technetium (99mTc) nofetumomab merpentan

Technetium (99mTc) nofetumomab merpentan


Trade names Verluma









Half-life 10.5 hours
Excretion renal (64%)


Identifiers
CAS Number 165942-79-0



ChemSpider none











Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]

Nofetumomab[edit]

Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5]

It is the Fab part of murine MAb NR-LU-10.[6]

Merpentan[edit]

The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6]

Phenthioate[edit]

Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7]

References[edit]

  1. ↑ "Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer".Clinical nuclear medicine.2000;25(1)
    54–5.doi:10.1097/00003072-200001000-00013.PMID:10634533.
  2. ↑ "Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy".Clinical nuclear medicine.1997;22(9)
    615–20.doi:10.1097/00003072-199709000-00007.PMID:9298295.
  3. ↑ WHO Drug Information
  4. ↑ Molecular Biology of B Cells. p533
  5. ↑ technetium (99mTc) nofetumomab merpentan (TAB-711)
  6. ↑ 6.0 6.1 Monoclonal Antibody Radionuclide Test Kits
  7. ↑ Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters US 3934010 A


Monoclonal antibodies for tumors
Tumor
Human
Mouse
Chimeric
Humanized
* Abituzumab§
Rat/mouse hybrid


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  • Technetium-99m nofetumomab merpentan skeletal structure
    Technetium-99m nofetumomab merpentan skeletal structure

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