Technetium (99mTc) nofetumomab merpentan

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Technetium-99m nofetumomab merpentan skeletal.svg



Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]

Nofetumomab[edit | edit source]

Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5]

It is the Fab part of murine MAb NR-LU-10.[6]

Merpentan[edit | edit source]

The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6]

Phenthioate[edit | edit source]

Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7]

References[edit | edit source]

  1. ↑
  2. ↑
  3. ↑ WHO Drug Information
  4. ↑ Molecular Biology of B Cells. p533
  5. ↑ technetium (99mTc) nofetumomab merpentan (TAB-711)
  6. ↑ 6.0 6.1 Monoclonal Antibody Radionuclide Test Kits
  7. ↑ Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters US 3934010 A



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Contributors: Prab R. Tumpati, MD