Technetium (99mTc) nofetumomab merpentan
| Technetium (99mTc) nofetumomab merpentan | |
|---|---|
|
| |
| Trade names | Verluma
|
| Half-life | 10.5 hours |
| Excretion | renal (64%)
|
| Identifiers | |
| CAS Number | 165942-79-0
|
| ChemSpider | none
|
Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]
Nofetumomab[edit]
Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5]
It is the Fab part of murine MAb NR-LU-10.[6]
Merpentan[edit]
The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6]
Phenthioate[edit]
Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7]
References[edit]
- ↑ "Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer".Clinical nuclear medicine.2000;25(1)
- 54–5.doi:10.1097/00003072-200001000-00013.PMID:10634533.
- ↑ "Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy".Clinical nuclear medicine.1997;22(9)
- 615–20.doi:10.1097/00003072-199709000-00007.PMID:9298295.
- ↑ WHO Drug Information
- ↑ Molecular Biology of B Cells. p533
- ↑ technetium (99mTc) nofetumomab merpentan (TAB-711)
- ↑ 6.0 6.1 Monoclonal Antibody Radionuclide Test Kits
- ↑ Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters US 3934010 A
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Technetium-99m nofetumomab merpentan skeletal structure
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