Technetium (99mTc) nofetumomab merpentan

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Technetium (99mTc) nofetumomab merpentan
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life 10.5 hours
Excretion renal (64%)
Legal status
CAS Number 165942-79-0
PubChem
DrugBank
ChemSpider none
KEGG

Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]

Nofetumomab[edit | edit source]

Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5]

It is the Fab part of murine MAb NR-LU-10.[6]

Merpentan[edit | edit source]

The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6]

Phenthioate[edit | edit source]

Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7]

References[edit | edit source]

  1. , Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer, Clinical nuclear medicine, 2000, Vol. 25(Issue: 1), pp. 54–5, DOI: 10.1097/00003072-200001000-00013, PMID: 10634533,
  2. , Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy, Clinical nuclear medicine, 1997, Vol. 22(Issue: 9), pp. 615–20, DOI: 10.1097/00003072-199709000-00007, PMID: 9298295,
  3. WHO Drug Information
  4. Molecular Biology of B Cells. p533
  5. technetium (99mTc) nofetumomab merpentan (TAB-711)
  6. 6.0 6.1 Monoclonal Antibody Radionuclide Test Kits
  7. Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters US 3934010 A



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