Technetium (99mTc) nofetumomab merpentan
| Technetium-99m nofetumomab merpentan skeletal.svg | |
Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]
Nofetumomab[edit | edit source]
Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5]
It is the Fab part of murine MAb NR-LU-10.[6]
Merpentan[edit | edit source]
The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6]
Phenthioate[edit | edit source]
Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7]
References[edit | edit source]
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