Elotuzumab

From WikiMD's Wellness Encyclopedia

What is Elotuzumab?[edit | edit source]

  • Elotuzumab (Empliciti) is a SLAMF7-directed immunostimulatory antibody used to treat people with multiple myeloma who have received one to three prior medications.


What are the uses of this medicine?[edit | edit source]

This medicine is used used to treat:

How does this medicine work?[edit | edit source]

  • Elotuzumab (el" oh tooz' ue mab) is humanized IgG1 monoclonal antibody to the cell surface receptor signaling lymphocyte activation molecule family member 7 (SLAMF7), which is a transmembrane glycoprotein that is frequently overexpressed on multiple myeloma cells and is found normally on natural killer (NK) cells.
  • The monoclonal antibody binds to the cell surface receptor and triggers cell apoptosis of cancer cells and activation of NK cells which may increase its antineoplastic activity.
  • In preregistration trials, the addition of elotuzumab to lenalidomide and dexamethasone led to an increase in overall response rates and prolongation of progression-free survival.

Who Should Not Use this medicine ?[edit | edit source]

  • This medicine have no usage limitations.

What drug interactions can this medicine cause?[edit | edit source]

  • Empliciti can interfere with assays used to monitor M-protein.
  • This interference can impact the determination of complete response.

Is this medicine FDA approved?[edit | edit source]

  • It was approved for use in the United States in 2015.

How should this medicine be used?[edit | edit source]

Recommended Dosage:

  • With lenalidomide and dexamethasone: 10 mg/kg administered intravenously every week for the first two cycles and every 2 weeks thereafter until disease progression or unacceptable toxicity.
  • With pomalidomide and dexamethasone: 10 mg/kg administered intravenously every week for the first two cycles and 20 mg/kg every 4 weeks thereafter until disease progression or unacceptable toxicity.

Administration

  • Empliciti will be given to you by intravenous (IV) infusion into your vein.
  • Your Empliciti treatment schedule is divided into cycles that are 28 days (4 weeks) long. A cycle includes the number of days you are on treatment and also the time you spend resting in between treatments.

Empliciti with REVLIMID and dexamethasone is usually given as follows:

  • Cycles 1 and 2 (28 days per cycle), you will receive Empliciti one time every week.
  • Cycles 3 and up (28 days per cycle), you will receive Empliciti one time every 2 weeks.

Empliciti with POMALYST and dexamethasone is usually given as follows:

  • Cycle 1 and 2 (28 days per cycle), you will receive Empliciti one time every week.
  • Cycle 3 and up (28 days per cycle), you will receive Empliciti one time every 4 weeks.
  • Your healthcare provider will decide how many treatments you will receive.
  • Before every Empliciti infusion, you will receive medicines to help reduce the risk of infusion reactions.
  • If you miss any appointments call your healthcare provider as soon as possible.

What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in fallowing doasage form:

  • As Injection: 300 mg or 400 mg lyophilized powder in a single-dose vial for reconstitution.

This medicine is available in fallowing brand namesː

  • Empliciti

What side effects can this medication cause?[edit | edit source]

The most common side effects of Empliciti when used with REVLIMID and dexamethasone include:

The most common side effects of Empliciti when used with POMALYST and dexamethasone include:

  • constipation
  • high blood sugar

Empliciti may cause serious side effects, including:

  • Infusion reactions
  • Infections
  • Risk of new cancers (malignancies)
  • Liver problems

What special precautions should I follow?[edit | edit source]

  • Empliciti can cause infusion reactions. Premedication is required. Interrupt Empliciti for Grade 2 or higher and permanently discontinue for severe infusion reaction.
  • Infections may occur. Monitor for fever and other signs of infection and treat promptly.
  • Higher incidences of SPM were observed in a controlled clinical trial of patients with multiple myeloma receiving Empliciti.
  • Hepatotoxicity were reported. Monitor liver function and stop Empliciti if hepatotoxicity is suspected.
  • Empliciti can interfere with assays used to monitor M-protein. This interference can impact the determination of complete response.

What to do in case of emergency/overdose?[edit | edit source]

  • The dose of Empliciti at which severe toxicity occurs is not known

Management of overdosage:

  • Empliciti does not appear to be removed by dialysis as determined in a study of patients with renal impairment.
  • In case of overdosage, monitor patients closely for signs or symptoms of adverse reactions and institute appropriate symptomatic treatment.

Can this medicine be used in pregnancy?[edit | edit source]

  • There are no available data on Empliciti use in pregnant women to inform a drug associated risk of major birth defects and miscarriage.

Can this medicine be used in children?[edit | edit source]

  • Safety and effectiveness have not been established in pediatric patients.

What are the active and inactive ingredients in this medicine?[edit | edit source]

  • Active ingredient: elotuzumab
  • Inactive ingredients: citric acid monohydrate, polysorbate 80, sodium citrate, sucrose

Who manufactures and distributes this medicine?[edit | edit source]

  • Manufactured by: Bristol-Myers Squibb Company, Princeton, NJ

What should I know about storage and disposal of this medication?[edit | edit source]

  • Store Empliciti under refrigeration at 2°C to 8°C (36°F-46°F).
  • Protect Empliciti from light by storing in the original package until time of use.
  • Do not freeze or shake.


Elotuzumab Resources
Wikipedia


Elotuzumab Resources
Wikipedia
WikiMD
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