Indium (111In) capromab pendetide
| Indium (111In) capromab pendetide | |
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| CAS Number | 151763-64-3 |
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| ChemSpider | none |
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Indium (111In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer.[1] Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA.[2] Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single photon emission computed tomography (SPECT).[1]
Early trials with yttrium (90Y) capromab pendetide were also conducted.[3]
References[edit | edit source]
- ↑ 1.0 1.1 , Indium-111 capromab pendetide in the management of recurrent prostate cancer, Expert Review of Anticancer Therapy, 2008, Vol. 8(Issue: 2), pp. 175–81, DOI: 10.1586/14737140.8.2.175, PMID: 18279057,
- ↑ WHO Drug Information
- ↑ Kahn, Daniel, A Phase II Study of [90Y] Yttrium-Capromab Pendetide in the Treatment of Men with Prostate Cancer Recurrence Following Radical Prostatectomy, Cancer Biotherapy & Radiopharmaceuticals, 1999, Vol. 14(Issue: 2), pp. 99, DOI: 10.1089/cbr.1999.14.99,
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