18-Deoxyaldosterone

What is 18-Deoxyaldosterone?[edit | edit source]

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18-Deoxyaldosterone

It is a steroidal antimineralocorticoid with mixed agonist–antagonist but predominantly antagonistic activity at the mineralocorticoid receptor^[1].
IUPAC Name: (2S,5S,6S,14R,15S,16S)-2-(2-hydroxyacetyl)-14-methyl-17-oxapentacyclo[14.2.1.01,5.06,15.09,14]nonadec-9-en-11-one
InChI: InChI=1S/C21H28O4/c1-20-7-6-13(23)8-12(20)2-3-14-15-4-5-16(17(24)10-22)21(15)9-18(19(14)20)25-11-21/h8,14-16,18-19,22H,2-7,9-11H2,1H3/t14-,15-,16+,18-,19+,20-,21?/m0/s1
InChI Key: ZEBLTAXSHAKMDJ-QBSCYWOBSA-N
Canonical SMILES: CC12CCC(=O)C=C1CCC3C2C4CC5(C3CCC5C(=O)CO)CO4
Isomeric SMILES: C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@@H]4CC5([C@H]3CC[C@@H]5C(=O)CO)CO4
Molecular formula: C21H28O4
Molecular weight: 344.4 g·mol−1
PubChem CID: 188963
Synonyms:

DTXSID30947934
21-Hydroxy-11,18-epoxypregn-4-ene-3,20-dione

^[2]

References[edit | edit source]

↑ Duax WL, Griffin JF, Strong PD, Funder JW, Ulick S (1982). "Molecular structure of 18-deoxyaldosterone and its relationship to receptor binding and activity". Journal of the American Chemical Society. 104 (25): 7291–7293. doi:10.1021/ja00389a063 [1].
↑ National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 188963, 18-Deoxyaldosterone. Retrieved August 6, 2021 from [2].

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[1] Duax WL, Griffin JF, Strong PD, Funder JW, Ulick S (1982). "Molecular structure of 18-deoxyaldosterone and its relationship to receptor binding and activity". Journal of the American Chemical Society. 104 (25): 7291–7293. doi:10.1021/ja00389a063 [1].

[2] National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 188963, 18-Deoxyaldosterone. Retrieved August 6, 2021 from [2].

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