Activated 7-dehydrocholesterol

Activated 7-dehydrocholesterol is a biochemical compound that plays a crucial role in the synthesis of vitamin D. It is a type of sterol, which are complex molecules that are involved in various biological processes, including cell membrane structure and signaling pathways.

Structure and Properties

Activated 7-dehydrocholesterol is a derivative of cholesterol. It has a similar structure to cholesterol, but with a double bond between the seventh and eighth carbon atoms in the B ring of the sterol nucleus. This double bond is what gives 7-dehydrocholesterol its unique properties and allows it to be converted into vitamin D.

Role in Vitamin D Synthesis

The synthesis of vitamin D begins in the skin, where ultraviolet B (UVB) radiation from the sun converts 7-dehydrocholesterol into pre-vitamin D3. This is a heat-dependent process, and the pre-vitamin D3 is then converted into cholecalciferol, or vitamin D3, through a heat-dependent process. This form of vitamin D is then transported to the liver and kidneys, where it is further converted into its active form, calcitriol.

Health Implications

Activated 7-dehydrocholesterol is essential for the production of vitamin D, which is necessary for the absorption of calcium and phosphate in the gut. These minerals are vital for the formation and maintenance of healthy bones and teeth. A deficiency in vitamin D can lead to conditions such as rickets in children and osteomalacia in adults, which are characterized by soft, weak bones.

In addition to its role in bone health, vitamin D is also involved in immune system function and may play a role in preventing certain types of cancer. Therefore, the role of 7-dehydrocholesterol in vitamin D synthesis is of great importance to human health.

See Also

• Cholesterol
• Vitamin D
• Sterol
• Rickets
• Osteomalacia