Arbaprostil
| Arbaprostil.svg | |
Arbaprostil is a synthetic analog of prostaglandin E1, a naturally occurring prostaglandin. It is primarily used in the medical field for its gastroprotective properties, particularly in the prevention and treatment of peptic ulcers.
Pharmacology[edit | edit source]
Arbaprostil functions by mimicking the action of natural prostaglandins in the body. Prostaglandins are lipid compounds that have diverse hormone-like effects, including the protection of the gastric mucosa. Arbaprostil exerts its effects by increasing the production of gastric mucus and bicarbonate, which help to protect the stomach lining from the corrosive effects of gastric acid. Additionally, it may reduce gastric acid secretion, further contributing to its protective effects.
Medical Uses[edit | edit source]
Arbaprostil is used in the management of peptic ulcer disease, particularly in patients who are at risk of developing ulcers due to the use of nonsteroidal anti-inflammatory drugs (NSAIDs). It is also used in the treatment of gastritis and other conditions where gastric mucosal protection is desired.
Side Effects[edit | edit source]
Common side effects of arbaprostil include diarrhea, abdominal pain, and nausea. These effects are generally mild and transient. However, as with any medication, there is a potential for more serious adverse effects, and arbaprostil should be used with caution in patients with certain medical conditions.
Mechanism of Action[edit | edit source]
Arbaprostil acts by binding to specific prostaglandin receptors in the stomach lining, leading to increased secretion of protective mucus and bicarbonate. This action helps to maintain the integrity of the gastric mucosa and prevent damage from gastric acid.
Chemical Properties[edit | edit source]
Arbaprostil is a synthetic compound with the chemical formula C20H34O5. It is a derivative of prostaglandin E1, modified to enhance its stability and efficacy as a therapeutic agent.
History and Development[edit | edit source]
Arbaprostil was developed as part of efforts to create synthetic prostaglandin analogs that could be used to treat gastrointestinal disorders. Its development was driven by the need for effective treatments for peptic ulcers, particularly in patients who require long-term NSAID therapy.
Also see[edit | edit source]
| Health science - Medicine - Gastroenterology - edit |
|---|
| Diseases of the esophagus - stomach |
| Halitosis | Nausea | Vomiting | GERD | Achalasia | Esophageal cancer | Esophageal varices | Peptic ulcer | Abdominal pain | Stomach cancer | Functional dyspepsia | Gastroparesis |
| Diseases of the liver - pancreas - gallbladder - biliary tree |
| Hepatitis | Cirrhosis | NASH | PBC | PSC | Budd-Chiari | Hepatocellular carcinoma | Acute pancreatitis | Chronic pancreatitis | Pancreatic cancer | Gallstones | Cholecystitis |
| Diseases of the small intestine |
| Peptic ulcer | Intussusception | Malabsorption (e.g. Coeliac, lactose intolerance, fructose malabsorption, Whipple's) | Lymphoma |
| Diseases of the colon |
| Diarrhea | Appendicitis | Diverticulitis | Diverticulosis | IBD (Crohn's, Ulcerative colitis) | IBS | Constipation | Colorectal cancer | Hirschsprung's | Pseudomembranous colitis |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
