CECXG

CECXG structure

CECXG, also recognized as 3'-ethyl-LY-341,495, is a specialized research drug of significant interest within the field of neuropharmacology. Its unique properties make it a potentially valuable tool for researchers studying the group II metabotropic glutamate receptors (mGluR2/3). Its ability to differentiate between mGluR2 and mGluR3, two closely related receptor subtypes, has garnered attention within the research community.

Pharmacological Profile

• Target Receptors: Group II metabotropic glutamate receptors (mGluR2/3).
• Action: Acts as an antagonist, which means it blocks or inhibits the function of the receptor it binds to.

Selectivity and Potency

• mGluR3 Selectivity: CECXG displays reasonable selectivity for mGluR3 over mGluR2, boasting an affinity that's 38 times higher for mGluR3 than for mGluR2. This distinctive feature places CECXG among the rare ligands capable of distinguishing between these two receptor subtypes.
• Comparison with LY-341,495: Although CECXG is roughly five times less potent than LY-341,495 at mGluR3, its enhanced specificity for mGluR3 over mGluR2 sets it apart.

Applications in Research

Given its unique characteristics, CECXG presents itself as a valuable compound for:

• Neuropharmacology research: To understand the roles and functions of mGluR2 and mGluR3 in the nervous system.
• Drug development: Could serve as a foundational molecule for the development of drugs targeting these receptors.
• Neurological disorders: To study the implications of mGluR2/3 in various neurological and psychiatric disorders.

Conclusion

CECXG's distinct pharmacological profile and its ability to selectively target and differentiate between mGluR2 and mGluR3 make it an invaluable tool in neuropharmacological research. While its full potential and applications are still under exploration, CECXG is a promising molecule that can yield insights into the functions of these metabotropic glutamate receptors and their implications in various conditions.

See Also

• Metabotropic Glutamate Receptor
• Neuropharmacology
• LY-341,495
• Antagonist

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