Ro01-6128

Ro01-6128 is a pharmacological compound that belongs to the class of benzodiazepine drugs. It is a psychoactive drug that possesses anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.

Pharmacology[edit | edit source]

Ro01-6128 is a benzodiazepine receptor agonist. It binds to the GABA (gamma-aminobutyric acid) receptors in the brain, enhancing the effects of this inhibitory neurotransmitter and leading to sedative and anxiolytic effects.

Medical Uses[edit | edit source]

Ro01-6128 is primarily used for the treatment of anxiety disorders, insomnia, seizures, and muscle spasms. It is also used as a premedication for medical or dental procedures to induce sedation and amnesia.

Side Effects[edit | edit source]

Common side effects of Ro01-6128 include drowsiness, dizziness, and impaired coordination. Long-term use can lead to physical dependence and withdrawal symptoms upon discontinuation.

History[edit | edit source]

Ro01-6128 was first synthesized in the 1970s by Roche, a Swiss multinational healthcare company. It is part of the larger family of benzodiazepine drugs, which were first discovered in the 1950s.

Benzodiazipines[edit source]

Anticonvulsants Drugs[edit source]

Drug class for Ro01-6128[edit source]

Anticonvulsants, and Benzodiazepines]

Template:Psychoactive drugs

Sedatives and Hypnotics[edit source]

Barbiturates

Benzodiazepines
- Diazepam
- Estazolam
- Flurazepam
- Quazepam
- Temazepam
- Triazolam

Benzodiazepine Receptor Agonists

Herbals
- Chamomile (Matricaria recutita)
- Hops (Humulus lupulus)
- Lavender (Lavandula angustifolia)
- Passionflower (Passiflora incarnata)
- Valerian (Valeriana officinalis)

Melatonin and its Analogues

Miscellaneous Agents

- Buspirone
- Chloral hydrate
- Doxepin
- Meprobamate
- Sodium Oxybate (Narcolepsy Agent)
- Suvorexant

Muscle relaxants

Template:Amnestics

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v t e Anxiolytics (N05B)
5-HT_1AR agonists	Buspirone Gepirone^† Tandospirone
GABA_AR PAMs	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carisoprodol Carbamates (e.g., meprobamate) Chlormezanone^‡ Ethanol (alcohol) Etifoxine Imepitoin; Herbs: Kava Skullcap Valerian
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIs (e.g., escitalopram) SNRIs (e.g., duloxetine) SARIs (e.g., trazodone) TCAs (e.g., clomipramine^#) TeCAs (e.g., mirtazapine) MAOIs (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cannabidiol Cycloserine Fabomotizole Hydroxyzine Kanna Lavender Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III