Fremanezumab-vfrm

What is Fremanezumab-vfrm?

Fremanezumab-vfrm (Ajovy) is a an FDA approved medication used in the preventive treatment of migraine in adults.

AJOVY

What are the uses of Fremanezumab-vfrm?

Ajovy is a calcitonin gene-related peptide antagonist indicated for the preventive treatment of migraine in adults.

How does Fremanezumab-vfrm work?

Fremanezumab-vfrm is a humanized monoclonal antibody that binds to calcitonin gene-related peptide (CGRP) ligand and blocks its binding to the receptor.

Who Should Not Use Fremanezumab-vfrm?

Ajovy is contraindicated in patients with serious hypersensitivity to fremanezumab-vfrm or to any of the excipients.

Is Fremanezumab-vfrm FDA approved?

Yes, on 09/14/2018 in the United States

How should Fremanezumab-vfrm be used?

• Two subcutaneous dosing options of ajovy are available to administer the recommended dosage:
• 225 mg monthly, or
• 675 mg every 3 months (quarterly)
• The 675 mg quarterly dosage is administered as three consecutive injections of 225 mg each.
• Administer in the abdomen, thigh, or upper arm subcutaneously.

What are the dosage forms and brand names of Fremanezumab-vfrm?

• Injection: 225 mg/1.5 ml solution in a single-dose prefilled autoinjector.
• Injection: 225 mg/1.5 ml solution in a single-dose prefilled syringe.

What side effects can Fremanezumab-vfrm cause?

• The most common adverse reactions (≥5% and greater than placebo) were injection site reactions.
• Allergic reactions, including itching, rash, and hives, can happen within hours and up to 1 month after receiving ajovy.
• Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms of an allergic reaction: Swelling of your face, mouth, tongue, or throat
• Trouble breathing

What special precautions should I follow?

Hypersensitivity reactions: if hypersensitivity occurs, consider discontinuing ajovy and institute appropriate therapy.

What to do in case of emergency/overdose?

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can Fremanezumab-vfrm be used in pregnancy?

• No. It is not known if ajovy will harm your unborn baby.
• Pregnancy registry: there is a registry for women who become pregnant during treatment with ajovy. The purpose of this registry is to collect information about the safety of ajovy during pregnancy. Contact the registry as soon as you learn that you are pregnant, or ask your doctor to contact the registry for you. You or your doctor can get information and enroll you in the registry by calling 1-833-927-2605 or visiting www.Tevamigrainepregnancyregistry.Com.
• It is not known if ajovy passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while using ajovy.

Can Fremanezumab-vfrm be used in children?

Not studied in children

What should I know about storage and disposal of Fremanezumab-vfrm?

• Store ajovy in the refrigerator between 36°f to 46°f (2°c to 8°c).
• Keep ajovy in the carton it comes in to protect from light.
• If needed, ajovy may be stored at room temperature up to 86°f (30°c) in the carton it comes in for up to 7 days. Do not use ajovy if it has been out of the refrigerator for 7 days or longer. Throw away (dispose of) ajovy in a sharps disposal or puncture-resistant container if it has been out of the refrigerator for 7 days or longer. Once stored at room temperature, do not place back in the refrigerator.
• Do not freeze. If ajovy freezes, throw it away in a sharps disposal container.
• Keep ajovy out of extreme heat and direct sunlight.
• Do not shake ajovy.
• Keep ajovy prefilled autoinjector and ajovy prefilled syringe out of the reach of small children.

What are the active and inactive ingredients in Fremanezumab-vfrm?=

Active ingredient: fremanezumab-vfrm

Who manufactures and distributes Fremanezumab-vfrm?

• Teva pharmaceuticals USA, Inc., North Wales, PA 19454

• Dailymed label info on Fremanezumab-vfrm
• FDA Fremanezumab-vfrm

Fremanezumab-vfrm Resources
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