GNA13

GNA13 is a protein that in humans is encoded by the GNA13 gene. It is a member of the G protein family, specifically the G12/13 subfamily. G proteins are involved in transmitting signals from a variety of stimuli outside a cell to its interior.

Function

The GNA13 protein is a guanine nucleotide-binding protein (G protein) which functions as a molecular switch inside cells. It is involved in regulating a variety of cellular processes including cell division, cell differentiation, and cell migration. GNA13 is particularly important in the regulation of angiogenesis and lymphangiogenesis, the formation of new blood vessels and lymphatic vessels, respectively.

Clinical significance

Mutations in the GNA13 gene have been associated with a variety of diseases. For example, it has been implicated in the development of cancer, particularly breast cancer and colorectal cancer. In addition, GNA13 has been linked to immune system disorders, such as rheumatoid arthritis and systemic lupus erythematosus.

Research

Research into the GNA13 gene and its associated protein is ongoing. Current areas of focus include understanding the precise role of GNA13 in cell signaling and investigating potential therapeutic applications for manipulating GNA13 activity in disease treatment.

See also

• G protein
• G12/13 subfamily
• Guanine nucleotide-binding protein
• Angiogenesis
• Lymphangiogenesis
• Cancer
• Breast cancer
• Colorectal cancer
• Immune system
• Rheumatoid arthritis
• Systemic lupus erythematosus

Cell biology