Idarubicin hydrochloride

What is Idarubicin hydrochloride?

Idarubicin hydrochloride (Idamycin PFS) a DNA-intercalating analog of daunorubicin used with other drugs to treat:

• Acute myeloid leukemia

Idarubicin

Idarubicin ball-and-stick

What are the uses of this medicine?

Idarubicin hydrochloride (Idamycin PFS) used with other drugs to treat:

• Acute myeloid leukemia (AML) in adults.

How does this medicine work?

• Idarubicin hydrochloride blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells.
• It is a type of anthracycline antibiotic and a type of topoisomerase inhibitor.
• Also called 4-demethoxydaunorubicin.
• Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis.
• The absence of a methoxy group at position 4 of the anthracycline structure gives high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds Idarubicin Hydrochloride, Organic Chemical, Pharmacologic Substance

Who Should Not Use this medicine ?

• This medicine have no usage limitations.

What drug interactions can this medicine cause?

Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following:

• certain cancer chemotherapy medications such as daunorubicin (cerubidine), doxorubicin (Doxil), epirubicin (Ellence), mitoxantrone(Novantrone), cyclophosphamide (Cytoxan), or trastuzumab (Herceptin)

How should this medicine be used?

Recommended dosage:

• Idarubicin hydrochloride injection 12 mg/m2 daily for 3 days by slow (10 to 15 min) intravenous injection in combination with cytarabine.
• The cytarabine may be given as 100 mg/m2 daily by continuous infusion for 7 days or as cytarabine 25 mg/m2 intravenous bolus followed by cytarabine 200 mg/m2 daily for 5 days continuous infusion.

Administration:

• Idarubicin comes as a solution (liquid) to be injected intravenously (into a vein) over 10 to 15 minutes by a doctor or nurse in a medical facility along with other chemotherapy medications.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Idarubicin Hydrochloride Injection available in 5 mL (5 mg), 10 mL (10 mg) and 20 mL (20 mg) single-use-only vials.

This medicine is available in fallowing brand namesː

• Idamycin PFS

What side effects can this medication cause?

The most common side effects of this medicine include:

• nausea
• vomiting
• diarrhea
• sores in the mouth and throat
• stomach pain
• headache
• joint pain
• hair loss
• rash
• redness and blisters on the palms and soles

What special precautions should I follow?

• Idarubicin Hydrochloride Injection should be given slowly into a freely flowing intravenous infusion. It must never be given intramuscularly or subcutaneously. Severe local tissue necrosis can occur if there is extravasation during administration.
• Idarubicin Hydrochloride can cause myocardial toxicity leading to congestive heart failure. Cardiac toxicity is more common in patients who have received prior anthracyclines or who have pre-existing cardiac disease.
• Severe myelosuppression occurs when idarubicin hydrochloride is used at effective therapeutic doses.
• It is recommended that idarubicin hydrochloride be administered only under the supervision of a physician who is experienced in leukemia chemotherapy and in facilities.
• Dosage should be reduced in patients with impaired hepatic or renal function. Frequent complete blood counts and monitoring of hepatic and renal function tests are recommended.

What to do in case of emergency/overdose?

Symptoms of overdosage may include:

• myelosuppression
• gastrointestinal toxicity
• acute cardiac toxicity
• mucositis

Management of overdosage:

* Adequate supportive care including platelet transfusions, antibiotics and symptomatic treatment of mucositis is required.

Can this medicine be used in pregnancy?

• There are no adequate and well-controlled studies in pregnant women.
• Women of childbearing potential should be advised to avoid pregnancy.

Can this medicine be used in children?

• Safety and effectiveness in pediatric patients have not been established.

What are the active and inactive ingredients in this medicine?

Active ingredients include:

• IDARUBICIN HYDROCHLORIDE

Inactive ingredients include:

• GLYCERIN
• HYDROCHLORIC ACID
• WATER

Who manufactures and distributes this medicine?

Manufactured by:

• THYMOORGAN PHARMAZIE GmbH,
• Schiffgraben 23, Goslar, Germany

Distributed by:

• West-Ward Pharmaceuticals
• Eatontown, NJ USA

What should I know about storage and disposal of this medication?

• Store under refrigeration 2° to 8°C (36° to 46°F), and protect from light.
• Retain in carton until time of use.

• Dailymed label info on Idarubicin hydrochloride
• FDA Idarubicin hydrochloride

Idarubicin hydrochloride Resources
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Idarubicin hydrochloride Resources
Latest articles Most recent articles Ongoing trials	Wikipedia