Spindle poison

From WikiMD's WELLNESSPEDIA

Other names[edit]

The term spindle poison is also known as a spindle toxin.

Definition[edit]

It is a poison that disrupts cell division by affecting the protein threads that connect the centromere regions of chromosomes, known as spindles.

Effects[edit]

Spindle poisons effectively cease the production of new cells by interrupting the mitosis phase of cell division at the spindle assembly checkpoint (SAC).

Limitations[edit]

However, Spindle poisons are not yet 100% effective at ending the formation of tumors (neoplasms).

Role in Chemotherapy[edit]

Although not 100% effective, substantive therapeutic efficacy has been found in these types of chemotherapeutic treatments.

Mitotic spindle[edit]

The mitotic spindle is composed of microtubules (polymerized tubulin) that aid, along with regulatory proteins; each other in the activity of appropriately segregating replicated chromosomes.

Example spindle poisons[edit]

Other examples include:

Mechanism of action[edit]

  • They exert their potent anti-neoplastic effects through activation of the spindle assembly checkpoint (SAC), thus arresting cells in mitosis.

Non-responders[edit]

  • Unfortunately, only certain cancers are susceptible to these drugs, and many patients fail to respond to treatment.
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