Griseofulvin
Griseofulvin is a fungistatic agent used to treat superficial fungal skin infections such as tinea capitis and tenia pedis.
Liver safety of Griseofulvin[edit source]
Griseofulvin therapy can cause transient mild-to-moderate serum aminotransferase elevations and has very rarely been linked to clinically apparent acute drug induced liver injury.
Mechanism of action of Griseofulvin[edit source]
- Griseofulvin (gris" ee oh ful' vin) is a metabolic product of Penicillium griseofulvum with potent activity against fungal agents.
- Its antifungal activity is believed to be due to disruption of the mitotic spindle of fungal cells, which interferes with cell division.
- Griseofulvin may also inhibit fungal DNA replication.
- Griseofulvin has been used for superficial dermatophyte infections (tinea corporis, tinea capitis, tinea barbae, tinea cruris, tinea pedis or tinea unguium) for many years.
Dosage and administration for Griseofulvin[edit source]
- The usual recommended dose is 500 to 1000 mg daily depending upon the type and severity of the infection.
Rarely used[edit | edit source]
- Griseofulvin is available in generic forms as tablets of 500 mg, and an oral suspension in several generic forms and under the brand names of Grifulvin V and as film coated tablets of 125 and 250 mg as Gris-PEG.
- Because of the availability of other more potent antifungal agents with a wider sprectum of action, griseofulvin is now rarely used.
Side effects of Griseofulvin[edit source]
Common side effects include nausea, vomiting and headache.
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Contributors: Kondreddy Naveen, Prab R. Tumpati, MD
