Fluconazole
Fluconazole (floo-KAH-nuh-zole)A drug that treats infections caused by fungi.
Information about Fluconazole[edit source]
Fluconazole is a triazole fungistatic agent used in the treatment of systemic and superficial fungal infections.
Liver safety of Fluconazole[edit source]
Fluconazole therapy can cause transient mild-to-moderate serum aminotransferase elevations and is a known cause of clinically apparent acute drug induced liver injury.
Mechanism of action of Fluconazole[edit source]
Fluconazole (floo kon' a zole) is a fungicidal agent which inhibits lanasterol-14-a-demethylase, the enzyme responsible for ergosterol synthesis. As a consequence, fluconazole causes an increase in abnormal intracellular sterols, inhibiting the fungal cell’s ability to replicate.
FDA approval information for Fluconazole[edit source]
Fluconazole was approved for use in the United States in 1990 and currently more than 12 million prescriptions are written for it yearly. Current indications include treatment of fungal infections due to candida and cryptococcus.
Brand name for Fluconazole[edit source]
Fluconazole is available in multiple generic forms and under the brand name Diflucan in tablets of 50, 100, 150 and 200 mg, as well as in oral suspensions and parenteral formulations.
Dosage and administration for Fluconazole[edit source]
The usual recommended dose is 100 to 400 mg daily, depending upon the type and severity of the infection.
Side effects of Fluconazole[edit source]
Common side effects include nausea, vomiting, and headache.
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