Metaplasia
(Redirected from Metaplastic bone)
Metaplasia[edit | edit source]
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Metaplasia is a pathological condition characterized by the transformation of one differentiated cell type to another differentiated cell type. This abnormal tissue change often occurs as an adaptive response to a chronic stimulus.
Definition and Types[edit | edit source]
Metaplasia can be classified into several types based on the tissue transformation:
- Epithelial Metaplasia: Changes in epithelial cell types, such as squamous metaplasia in the respiratory tract.
- Mesenchymal Metaplasia: Transformation of mesenchymal tissue, like bone formation in soft tissue.
Causes[edit | edit source]
Common causes of metaplasia include:
- Chronic irritation or inflammation
- Hormonal changes
- Environmental factors, such as smoking
Clinical Significance[edit | edit source]
Metaplasia is significant clinically as it can be a precursor to dysplasia and malignant transformations. However, not all metaplastic changes lead to cancer.
Potential for Malignancy[edit | edit source]
While metaplasia is initially a benign process, chronic conditions leading to persistent metaplasia can increase the risk of developing malignancy in the affected tissues.
External Links[edit | edit source]
- National Cancer Institute - Definition of Metaplasia
- National Center for Biotechnology Information - Metaplasia
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