Moexipril hydrochloride

Moexipril hydrochloride is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension. It is a prodrug that is converted to its active metabolite, moexiprilat, in the body.

Pharmacology

Moexipril hydrochloride is a prodrug that is metabolized in the liver to its active form, moexiprilat. This active metabolite inhibits the angiotensin converting enzyme (ACE), which is involved in the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor and stimulates the release of aldosterone, a hormone that increases sodium reabsorption by the kidneys. By inhibiting the production of angiotensin II, moexipril hydrochloride reduces vasoconstriction and decreases sodium and water reabsorption, leading to a decrease in blood pressure.

Clinical Use

Moexipril hydrochloride is used in the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. The drug is typically taken once or twice daily, with or without food. The dosage is adjusted based on the patient's response to treatment and other medical conditions.

Side Effects

Common side effects of moexipril hydrochloride include cough, dizziness, and headache. Serious side effects may include angioedema, kidney problems, and high potassium levels. It is contraindicated in patients with a history of angioedema related to previous treatment with an ACE inhibitor and in patients with bilateral renal artery stenosis.

Interactions

Moexipril hydrochloride may interact with other medications, including diuretics, potassium supplements, and nonsteroidal anti-inflammatory drugs (NSAIDs). These interactions can increase the risk of side effects or decrease the effectiveness of the drug.

See Also

• Angiotensin converting enzyme (ACE) inhibitors
• Hypertension
• Prodrug